Diphtheria toxin

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Revision as of 10:47, 24 February 2019

Structure of diphtheria toxin complex with adenylyl-UMP (PDB code 1ddt).

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Updated on 24-February-2019

↑ Pappenheimer AM Jr. Diphtheria toxin. Annu Rev Biochem. 1977;46:69-94. PMID:20040 doi:http://dx.doi.org/10.1146/annurev.bi.46.070177.000441
↑ Bennett MJ, Choe S, Eisenberg D. Refined structure of dimeric diphtheria toxin at 2.0 A resolution. Protein Sci. 1994 Sep;3(9):1444-63. PMID:7833807

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 == Structural highlights ==
-<scene name='59/592684/Cv/6'>The biological assembly of Diphtheria toxin is dimer</scene>. DT is proteolitically cleaved into 2 fragments. <scene name='59/592684/Cv/7'>Fragment A contains the catalytic domain (C)</scene> and <scene name='59/592684/Cv/8'>fragment B</scene> contains the <scene name='59/592684/Cv/9'>transmembrane (T)</scene> and <scene name='59/592684/Cv/10'>receptor-binding (R)</scene> domains.  <scene name='59/592684/Cv/14'>DT active site</scene> is located in a cleft in the C domain.<ref>PMID:7833807</ref> The 2 monomers of DT interact by domain swapping to form a <scene name='59/592684/Cv/10'>compact, globular dimer structure</scene>.
+<scene name='59/592684/Cv/17'>The biological assembly of Diphtheria toxin is dimer</scene>. DT is proteolitically cleaved into 2 fragments. <scene name='59/592684/Cv/7'>Fragment A contains the catalytic domain (C)</scene> and <scene name='59/592684/Cv/8'>fragment B</scene> contains the <scene name='59/592684/Cv/9'>transmembrane (T)</scene> and <scene name='59/592684/Cv/10'>receptor-binding (R)</scene> domains.  <scene name='59/592684/Cv/15'>DT active site</scene> is located in a cleft in the C domain.<ref>PMID:7833807</ref> Water molecules are shown as red spheres. The 2 monomers of DT interact by domain swapping to form a <scene name='59/592684/Cv/16'>compact, globular dimer structure</scene>.
 </StructureSection>