5zm5

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'''Unreleased structure'''
 
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The entry 5zm5 is ON HOLD until Paper Publication
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==Crystal structure of human ORP1-ORD in complex with cholesterol at 2.6 A resolution==
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<StructureSection load='5zm5' size='340' side='right' caption='[[5zm5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5zm5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZM5 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zm5 OCA], [http://pdbe.org/5zm5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zm5 RCSB], [http://www.ebi.ac.uk/pdbsum/5zm5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zm5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/OSBL1_HUMAN OSBL1_HUMAN]] Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).<ref>PMID:16176980</ref> <ref>PMID:17428193</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Dong, J]]
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[[Category: Wang, J]]
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[[Category: Wu, J W]]
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[[Category: Complex]]
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[[Category: Lipid transport]]
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[[Category: Transporter]]

Revision as of 15:12, 27 February 2019

Crystal structure of human ORP1-ORD in complex with cholesterol at 2.6 A resolution

5zm5, resolution 2.60Å

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