2o07
From Proteopedia
| Line 37: | Line 37: | ||
[[Category: Wu, H.]] | [[Category: Wu, H.]] | ||
[[Category: Zeng, H.]] | [[Category: Zeng, H.]] | ||
| - | [[Category: | + | [[Category: Sgc]] |
| - | [[Category: | + | [[Category: Spermidine synthase]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Structural genomics consortium]] |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat Apr 5 19:11:32 2008'' |
Revision as of 16:11, 5 April 2008
| |||||||
| , resolution 1.89Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | SRM, SPS1 (Homo sapiens) | ||||||
| Activity: | Spermidine synthase, with EC number 2.5.1.16 | ||||||
| Related: | 2O05, 2O06, 2O0L
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Human spermidine synthase
Overview
Aminopropyltransferases transfer aminopropyl groups from decarboxylated S-adenosylmethionine to amine acceptors, forming polyamines. Structural and biochemical studies have been carried out with the human spermidine synthase, which is highly specific for putrescine as the amine acceptor, and the Thermotoga maritima spermidine synthase, which prefers putrescine but is more tolerant of other substrates. Comparison of the structures of the human spermidine synthase with both substrates and products with the known structure of T. maritima spermidine synthase complexed to a multisubstrate analogue inhibitor and analysis of the properties of site-directed mutants provide a general mechanistic hypothesis for the aminopropyl transfer reaction. The studies also provide a structural basis for the specificity of the spermidine synthase subclass of the aminopropyltransferase family.
About this Structure
2O07 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure and mechanism of spermidine synthases., Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN, Biochemistry. 2007 Jul 17;46(28):8331-9. Epub 2007 Jun 22. PMID:17585781
Page seeded by OCA on Sat Apr 5 19:11:32 2008
Categories: Homo sapiens | Single protein | Spermidine synthase | Arrowsmith, C H. | Bochkarev, A. | Edwards, A M. | Loppnau, P. | Min, J. | Plotnikov, A N. | SGC, Structural Genomics Consortium. | Sundstrom, M. | Weigelt, J. | Wu, H. | Zeng, H. | Sgc | Structural genomic | Structural genomics consortium
