6nhw
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the transmembrane domain of the Death Receptor 5 - Dimer of Trimer== | |
| - | + | <StructureSection load='6nhw' size='340' side='right' caption='[[6nhw]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6nhw]] is a 6 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NHW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nhw OCA], [http://pdbe.org/6nhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nhw RCSB], [http://www.ebi.ac.uk/pdbsum/6nhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nhw ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chen, W]] | ||
| + | [[Category: Chou, J J]] | ||
[[Category: Fu, Q]] | [[Category: Fu, Q]] | ||
[[Category: Fu, T]] | [[Category: Fu, T]] | ||
| + | [[Category: Pan, L]] | ||
[[Category: Piai, A]] | [[Category: Piai, A]] | ||
| - | [[Category: | + | [[Category: Wu, H]] |
| - | + | ||
[[Category: Zhao, L]] | [[Category: Zhao, L]] | ||
| - | [[Category: | + | [[Category: Death receptor 5]] |
| - | [[Category: | + | [[Category: Immune system]] |
| + | [[Category: Preligand autoinhibition]] | ||
| + | [[Category: Transmembrane helix mediated signaling]] | ||
| + | [[Category: Transmembrane helix oligomer]] | ||
Revision as of 15:31, 27 February 2019
Structure of the transmembrane domain of the Death Receptor 5 - Dimer of Trimer
| |||||||||||
