6nhy

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'''Unreleased structure'''
 
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The entry 6nhy is ON HOLD until Paper Publication
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==Structure of the transmembrane domain of the Death Receptor 5 mutant (G217Y) - Trimer Only==
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<StructureSection load='6nhy' size='340' side='right' caption='[[6nhy]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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Authors: Chou, J.J., Pan, L., Zhao, L., Chen, W., Piai, A., Fu, T., Wu, H., Liu, Z.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6nhy]] is a 3 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NHY FirstGlance]. <br>
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Description: Structure of the transmembrane domain of the Death Receptor 5 mutant (G217Y) -Trimer Only
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nhy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nhy OCA], [http://pdbe.org/6nhy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nhy RCSB], [http://www.ebi.ac.uk/pdbsum/6nhy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nhy ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Pan, L]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.
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== Function ==
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[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chen, W]]
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[[Category: Chou, J J]]
[[Category: Fu, T]]
[[Category: Fu, T]]
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[[Category: Chou, J.J]]
 
[[Category: Liu, Z]]
[[Category: Liu, Z]]
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[[Category: Zhao, L]]
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[[Category: Pan, L]]
[[Category: Piai, A]]
[[Category: Piai, A]]
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[[Category: Chen, W]]
 
[[Category: Wu, H]]
[[Category: Wu, H]]
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[[Category: Zhao, L]]
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[[Category: Immune system]]
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[[Category: Transmembrane helix trimer]]

Revision as of 15:31, 27 February 2019

Structure of the transmembrane domain of the Death Receptor 5 mutant (G217Y) - Trimer Only

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