6nzw

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m (Protected "6nzw" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6nzw is ON HOLD
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==LRRC8A-DCPIB in MSP1E3D1 nanodisc constricted state==
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<StructureSection load='6nzw' size='340' side='right' caption='[[6nzw]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
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Authors: Kern, D.M., Hite, R.K., Brohawn, S.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6nzw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NZW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NZW FirstGlance]. <br>
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Description: LRRC8A-DCPIB in MSP1E3D1 nanodisc constricted state
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L9Y:4-{[(2S)-2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl]oxy}butanoic+acid'>L9Y</scene>, <scene name='pdbligand=POV:(2S)-3-(HEXADECANOYLOXY)-2-[(9Z)-OCTADEC-9-ENOYLOXY]PROPYL+2-(TRIMETHYLAMMONIO)ETHYL+PHOSPHATE'>POV</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nzw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nzw OCA], [http://pdbe.org/6nzw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nzw RCSB], [http://www.ebi.ac.uk/pdbsum/6nzw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nzw ProSAT]</span></td></tr>
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[[Category: Brohawn, S.G]]
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</table>
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[[Category: Kern, D.M]]
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== Function ==
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[[Category: Hite, R.K]]
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[[http://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE]] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Brohawn, S G]]
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[[Category: Hite, R K]]
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[[Category: Kern, D M]]
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[[Category: Ion channel]]
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[[Category: Membrane protein]]
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[[Category: Volume-regulation]]

Revision as of 15:33, 27 February 2019

LRRC8A-DCPIB in MSP1E3D1 nanodisc constricted state

6nzw, resolution 3.21Å

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