6o00
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==apo-LRRC8A in MSP2N2 nanodisc constricted state== | |
| - | + | <StructureSection load='6o00' size='340' side='right' caption='[[6o00]], [[Resolution|resolution]] 4.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6o00]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O00 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O00 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6nzw|6nzw]], [[6nzz|6nzz]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o00 OCA], [http://pdbe.org/6o00 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o00 RCSB], [http://www.ebi.ac.uk/pdbsum/6o00 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o00 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Kern, D | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE]] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brohawn, S G]] | ||
| + | [[Category: Hite, R K]] | ||
| + | [[Category: Kern, D M]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Volume-regulation]] | ||
Revision as of 15:33, 27 February 2019
apo-LRRC8A in MSP2N2 nanodisc constricted state
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