Human Keto Acyl Reductase

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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Function ==3-Ketoacyl-acyl carrier protein (ACP) reductase (KAR) catalyses the second step of the mtFAS pathway . Although all the other mtFAS enzymes identified thus far are encoded by single genes, human KAR (HsKAR) is a heterotetrametric α2β2 enzyme formed by two subunits, 17β-hydroxysteroid dehydrogenase type 8 (HSD17B8 or KE6, α-subunit) and carbonyl reductase type 4 (CBR4 or SDR45C1, β-subunit)9. HsHSD17B8 is expressed in abundance in the prostate, placenta and kidney, and has been shown to catalyse the reversible oxidation/reduction of steroid molecules in vitro. The physiological roles of HSD17B8 and CBR4 have remained elusive, and information is only available from studies of the respective homotetramers.
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== Function == Keto acyl carrier protein reductase (KAR) is a heterotetrameric complex made from two different polypeptides: 17β-hydroxysteroid dehydrogenase type 8 (HSD17B8 or KE6, α-subunit) and carbonyl reductase type 4 (CBR4 or SDR45C1, β-subunit)9. it catalyzes the second step of the mitochondrial fatty acid synthesis (mtFAS) pathway.
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== Disease == There is evidence for physiologically relevant products of mtFAS in yeast6. Deficiency of mtFAS leads to respiratory chain defects and mitochondrial dysfunction
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== Disease == Deficiency of the KAR or mtFAS leads to respiratory chain defects and mitochondrial dysfunction.
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== Relevance == mtFAS provides the precursor of mitochondrially synthesized α-lipoic acid, a key cofactor for oxidative decarboxylation of α-keto acids and glycine within eukaryotic cells5. There is evidence for other physiologically relevant products of mtFAS in yeast6. Deficiency of mtFAS leads to respiratory chain defects and mitochondrial dysfunction
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== Relevance ==
== Structural highlights ==
== Structural highlights ==

Revision as of 12:38, 28 February 2019

==Your Heading Here (maybe something like 'Structure')==Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

Proteopedia Page Contributors and Editors (what is this?)

Shiv K. Sah-Teli, Rajaram Venkatesan, Michal Harel

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