Human Keto Acyl Reductase
From Proteopedia
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | == Function == Keto acyl carrier protein reductase (KAR) is a heterotetrameric complex made from two different polypeptides: 17β-hydroxysteroid dehydrogenase type 8 (HSD17B8 or KE6, α-subunit) and carbonyl reductase type 4 (CBR4 or SDR45C1, β-subunit)9. it catalyzes the second step of the mitochondrial fatty acid synthesis (mtFAS) pathway | + | == Function == Keto acyl carrier protein reductase (KAR) is a heterotetrameric complex made from two different polypeptides: 17β-hydroxysteroid dehydrogenase type 8 (HSD17B8 or KE6, α-subunit) and carbonyl reductase type 4 (CBR4 or SDR45C1, β-subunit)9. it catalyzes the second step of the mitochondrial fatty acid synthesis (mtFAS) pathway <ref/PMID 25203508> |
== Disease == Deficiency of the KAR or mtFAS leads to respiratory chain defects and mitochondrial dysfunction. | == Disease == Deficiency of the KAR or mtFAS leads to respiratory chain defects and mitochondrial dysfunction. | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
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Revision as of 12:46, 28 February 2019
==Your Heading Here (maybe something like 'Structure')==Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP
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References
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