Adhesin

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== 3D Structures of adhesin ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Fimbrial adhesin
 
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**[[4k0o]], [[2bs8]], [[2bsc]], [[2bsb]], [[5nwp]] – EcF17b-G lectin domain – ''Escherichia coli'' <BR />
 
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**[[1o9z]], [[1o9w]], [[1o9v]] – EcF17a-G lectin domain <BR />
 
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**[[5vq5]] – EcF17 lectin domain (mutant) <BR />
 
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**[[1oio]] – EcF17c lectin domain <BR />
 
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**[[4b4p]], [[4bwo]] – EcF18 lectin domain <BR />
 
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**[[4auu]], [[1uwf]], [[1tr7]], [[5fwr]] – EcAdh FimH lectin domain <BR />
 
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**[[5mca]], [[5fx3]], [[5fs5]] – EcAdh FimH lectin domain (mutant) <BR />
 
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**[[5afo]] – EcAdh LF82 <BR />
 
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**[[6aow]] – EcAdh FMLH lectin domain <BR />
 
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**[[3zk7]] – SpPsaA - ''Streptococcus pneumoniae'' <br />
 
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**[[3zk8]], [[3zk9]], [[3zka]] – SpPsaA (mutant)<br />
 
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**[[3u4k]] – Adh lectin domain – ''Klebsiella pneumoniae''<BR />
 
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**[[6h1q]] – Adh – ''Proteus mirabilis'' <br />
 
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*Fimbrial adhesion complexes
 
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**[[4b4q]], [[4b4r]] – EcF18 lectin domain + hexasaccharide <BR />
 
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**[[4w6w]], [[4w6x]], [[4w6y]] – EcF18 lectin domain + nanobody <BR />
 
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**[[4j3o]] – EcAdh FimH + FimG + FimC + FimF + FimD <BR />
 
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**[[6e14]], [[6e15]] – EcAdh FimH + FimG + FimC + FimF + FimD - Cryo EM<BR />
 
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**[[3rfz]], [[1ze3]] – EcAdh FimH + FimC + FimD <BR />
 
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**[[1qun]], [[1klf]], [[1kiu]] – EcAdh FimH + FimC <BR />
 
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**[[4xo9]] – EcAdh FimH + DSG residues 24-37 <BR />
 
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**[[4xod]], [[4xoa]] – EcAdh FimH + FimG residues 24-37 <BR />
 
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**[[4xob]] – EcAdh FimH + FimF residues 24-37 + mannoside derivative<BR />
 
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**[[5jr4]], [[5jqi]] – EcAdh FimH (mutant) + FimG N-terminal <BR />
 
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**[[6as8]], [[6arm]], [[6aoy]] – EcAdh FMLD lectin domain + galactoside derivative <BR />
 
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**[[6aox]] – EcAdh FMLD lectin domain + TF antigen <BR />
 
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**[[6aro]] – EcAdh FMLH lectin domain + quinoline derivative <BR />
 
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**[[5muc]], [[5l4y]], [[5l4x]], [[5l4w]], [[5l4v]], [[5l4u]], [[5l4t]], [[5jcq]], [[5jcr]], [[5f2f]], [[5f3f]], [[5abz]], [[4xo8]], [[4x5p]], [[4x5q]], [[4x5r]], [[4lov]], [[4css]], [[4cst]], [[4att]], [[4auj]], [[4auy]], [[4av0]], [[4av4]], [[4av5]], [[4avh]], [[4avi]], [[4avj]], [[4avk]], [[3zl1]], [[3zl2]], [[2vco]], [[6gtx]], [[6gty]] – EcAdh FimH lectin domain + mannoside derivative <BR />
 
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**[[5cgb]] – EcAdh FimH lectin domain + galactitol <BR />
 
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**[[5ab1]], [[4x50]] – EcAdh FimH + mannoside derivative <BR />
 
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**[[5aap]], [[5aal]], [[5mts]] – EcAdh FimH lectin domain + anti-adhesive <BR />
 
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**[[3f6j]], [[3f64]], [[1zpl]], [[1zk5]] – EcF17a-G lectin domain + GlcNAc derivative <BR />
 
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**[[1psz]] – SpPsaA + Zn – ''Streptococcus pneumonia''<br />
 
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**[[3ztt]] – SpPsaA + Mn<br />
 
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**[[4utp]], [[4uto]] – SpPsaA + Cd<br />
 
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**[[2bs7]] – EcF17b-G lectin domain + chitobiose <BR />
 
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**[[3ffo]] – EcF17b-G lectin domain + GlcNac-Man <BR />
 
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**[[4b4q]], [[4b4r]] – EcFedF lectin domain + hexasaccharide <BR />
 
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**[[4w6w]], [[4w6x]], [[4w6y]] – EcFedF lectin domain + nanobody <BR />
 
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**[[4f8l]] – YpPsaA + galactose + inhibitor – ''Yersinia pestis'' <BR />
 
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**[[4f8n]] – YpPsaA + galactose + phosphate choline <BR />
 
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**[[4f8o]] – YpPsaA + lactose + inhibitor <BR />
 
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**[[4f8p]] – YpPsaA + galactose <BR />
 
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*Epitheial adhesin
 
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**[[4d3w]], [[4asl]], [[4af9]] – CgAdh epithelial 1 A domain – ''Candida glabrata''<br />
 
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**[[4afc]], [[4afb]], [[4afa]] – CgAdh epithelial 1 A domain (mutant)<br />
 
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**[[4cp2]], [[4cp1]], [[4cp0]] – CgAdh epithelial 9 A domain <br />
 
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**[[4coz]], [[4coy]], [[4cow]], [[4cov]], [[4cou]] – CgAdh epithelial 6 A domain <br />
 
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*Collagen adhesin (CAdh)
 
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**[[1amx]] – SaCAdh CBD – ''Staphylococcus aureus''<br />
 
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**[[1d2o]] – SaCAdh B1 repeat unit<br />
 
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**[[1d2p]] – SaCAdh B1-B2 repeat units<br />
 
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**[[2f68]] – SaCAdh extracellular domain<br />
 
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**[[2f6a]] – SaCAdh extracellular domain + collagen<br />
 
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**[[2okm]], [[2z1p]] – CAdh CBD – ''Enterococcus faecalis''<br />
 
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**[[1p9h]] – YeYadA CBD – ''Yersinia enterocolitica''<br />
 
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**[[3h7x]] – YeYadA stalk domain<br />
 
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**[[3h7z]] – YeYadA stalk domain (mutant)<br />
 
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**[[3lt6]], [[3lt7]] – YeYadA coiled coil<br />
 
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**[[2lme]] – YeYadA coiled coil - NMR<br />
 
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*Serine-rich adhesin for platelets (SRAP)
 
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**[[4m00]] – SaSRAP LBD<br />
 
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**[[4m01]] – SaSRAP LBD N-terminal<br />
 
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**[[4m02]] – SaSRAP LBD middle region<br />
 
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**[[4m03]] – SaSRAP LBD C-terminal<br />
 
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*Adhesin
 
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**[[2odl]], [[2gr8]], [[2gr7]] – HiAdh secretion domain – ''Haemophilus influenzae''<br />
 
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**[[3emf]] – HiAdh residues 51-166<br />
 
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**[[3emi]] – HiAdh residues 307-422 (mutant)<br />
 
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**[[1s7m]] – HiAdh residues 548-706<br />
 
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**[[3emo]] – HiAdh residues 937-1098<br />
 
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**[[4zh7]], [[4zh0]] – Adh BABA – ''Helicobacter pylori''<br />
 
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**[[4usx]] – Adh trimeric autotransporter – ''Burkholderia pseudomallei''<br />
 
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**[[3wqa]], [[3wpr]], [[3wpp]], [[3wpo]], [[3wpa]] – AcAdh trimeric autotransporter C-terminal – ''Acinetobacter''<br />
 
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**[[3wp8]] – AcAdh trimeric autotransporter C-terminal (mutant)<br />
 
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**[[4err]] – Adh autotransporter effector domain – ''Vibrio vulnificus''<br />
 
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**[[2wps]], [[2wpr]], [[2wpq]] – Adh trimeric autotransporter residues 483-523 – ''Salmonella enterica''<br />
 
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**[[4tsh]] – Adh surface protein – ''Streptococcus mutans''<br />
 
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**[[4mee]] – EcAdh diffuse adherence C-terminal <br />
 
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**[[5lvy]] – EcAdh lectin domain <BR />
 
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**[[3etw]] – FnAdh A – ''Fusobacterium nucleatum'' <BR />
 
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**[[3etz]], [[3ety]], [[3etx]], [[2gl2]] – FnAdh A (mutant) <BR />
 
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**[[3d9x]] – Adh A – ''Bartonella henselae'' <BR />
 
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**[[2lwb]] – Adh WI-1 – ''Ajellomyces dermatitidis'' <BR />
 
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**[[5my7]] – NmAdh residues 1-124 – ''Neisseria meningitidis'' <BR />
 
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**[[6eun]] – NmAdh residues 24-170<BR />
 
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**[[6eup]] – NmAdh residues 24-170 (mutant)<BR />
 
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**[[6gq4]] – Adh residues 83-185 – ''Neisseria gonorheae''<BR />
 
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}}
 

Revision as of 09:35, 3 March 2019

Adhesin PsaA complex with tert-butyl formate and galactose (stick model) (PDB ID 4f8p)

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References

  1. ↑ Klemm P, Schembri MA. Bacterial adhesins: function and structure. Int J Med Microbiol. 2000 Mar;290(1):27-35. PMID:11043979 doi:http://dx.doi.org/10.1016/S1438-4221(00)80102-2
  2. ↑ Nishiyama M, Ishikawa T, Rechsteiner H, Glockshuber R. Reconstitution of pilus assembly reveals a bacterial outer membrane catalyst. Science. 2008 Apr 18;320(5874):376-9. doi: 10.1126/science.1154994. Epub 2008 Mar, 27. PMID:18369105 doi:http://dx.doi.org/10.1126/science.1154994
  3. ↑ Wizemann TM, Adamou JE, Langermann S. Adhesins as targets for vaccine development. Emerg Infect Dis. 1999 May-Jun;5(3):395-403. doi: 10.3201/eid0503.990310. PMID:10341176 doi:http://dx.doi.org/10.3201/eid0503.990310
  4. ↑ Bao R, Nair MK, Tang WK, Esser L, Sadhukhan A, Holland RL, Xia D, Schifferli DM. Structural basis for the specific recognition of dual receptors by the homopolymeric pH 6 antigen (Psa) fimbriae of Yersinia pestis. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1065-70. doi:, 10.1073/pnas.1212431110. Epub 2012 Dec 31. PMID:23277582 doi:10.1073/pnas.1212431110

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