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Albumin

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The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments.
The binding mode of <scene name='Journal:JBSD:26/Cv/2'>erlotinib hydrochloride (ET)</scene>, a targeted anticancer drug, to <scene name='Journal:JBSD:26/Cv/8'>bovine serum albumin (BSA)</scene> was investigated through 1H NMR, spectroscopic, thermodynamic and molecular modeling methods. Each subdomain is marked with a different colour (<font color='red'><b>red for subdomain IA</b></font>; <span style="color:orange;background-color:black;font-weight:bold;">orange, IB</span>; <span style="color:cyan;background-color:black;font-weight:bold;">cyan, IIA</span>; <span style="color:yellow;background-color:black;font-weight:bold;">yellow, IIB</span>; <span style="color:lime;background-color:black;font-weight:bold;">green, IIIA</span>; <font color='darkmagenta'><b>darkmagenta, IIIB</b></font>). From these methods, the binding parameters, binding site, binding distance, and conformational changes were obtained. Site marker competitive experiments demonstrated that the <scene name='Journal:JBSD:26/Cv/6'>binding site was located in the hydrophobic pocket of site I (subdomain IIA)</scene>. The docking modeling agreed with the results of the fluorescence and displacement experiments.
 +
 +
== 3D Structures of albumin ==
 +
[[Albumin 3D structures]]
 +
</StructureSection>
</StructureSection>
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*Human serum albumin
*Human serum albumin
-
**[[1e78]], [[1bm0]], [[1ao6]], [[1uor]], [[3sqj]], [[4g03]], [[4g04]], [[4k2c]] - hSA – human
+
**[[1e78]], [[1bm0]], [[1ao6]], [[1uor]], [[3sqj]], [[4g03]], [[4g04]], [[4k2c]], [[5z0b]] - hSA – human
*Human serum albumin binary complex
*Human serum albumin binary complex
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**[[2ydf]] – hSA + iophenoxic acid<br />
**[[2ydf]] – hSA + iophenoxic acid<br />
**[[2xvq]], [[2xvu]], [[2xw0]], [[2xw1]] - hSA + dansyl derivative<br />
**[[2xvq]], [[2xvu]], [[2xw0]], [[2xw1]] - hSA + dansyl derivative<br />
-
**[[3lu6]], [[3ju7]], [[3lu8]], [[2bx8]], [[2bxa]], [[2bxb]], [[2bxc]], [[2bxd]], [[2bxe]], [[2bxf ]], [[2bxg]], [[2bxh]], [[2bxi]], [[2bxk]], [[2bxl]], [[2bxm]], [[2bxn]],[[2bxo]], [[2bxp]], [[2bxq]], [[3lu7]], [[4l8u]], [[4l9k]], [[4l9q]], [[4la0]], [[4lb2]], [[4lb9]], [[5ifo]], [[5id9]], [[5id7]], [[5gix]], [[5giy]] – hSA + drug<br />
+
**[[3lu6]], [[3ju7]], [[3lu8]], [[2bx8]], [[2bxa]], [[2bxb]], [[2bxc]], [[2bxd]], [[2bxe]], [[2bxf ]], [[2bxg]], [[2bxh]], [[2bxi]], [[2bxk]], [[2bxl]], [[2bxm]], [[2bxn]],[[2bxo]], [[2bxp]], [[2bxq]], [[3lu7]], [[4l8u]], [[4l9k]], [[4l9q]], [[4la0]], [[4lb2]], [[4lb9]], [[5ifo]], [[5id9]], [[5id7]], [[5gix]], [[5giy]], [[5yb1]] – hSA + drug<br />
**[[4iw1]], [[4iw2]] – hSA + monosaccharide<br />
**[[4iw1]], [[4iw2]] – hSA + monosaccharide<br />
**[[3jqz]] – hSA + lidocaine<br />
**[[3jqz]] – hSA + lidocaine<br />
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**[[4hgk]], [[4hgm]], [[5fuo]] – hSA + shark antibody<br />
**[[4hgk]], [[4hgm]], [[5fuo]] – hSA + shark antibody<br />
**[[5vnw]] – hSA + nanobody<br />
**[[5vnw]] – hSA + nanobody<br />
 +
**[[6a7p]] – hSA + apipiprazole<br />
*Human serum albumin ternary complex
*Human serum albumin ternary complex
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**[[3v03]], [[4f5s]] - bSA – bovine<br />
**[[3v03]], [[4f5s]] - bSA – bovine<br />
 +
**[[4jk4]] – bSA + diiodosalicilate<br />
 +
**[[4or0]] – bSA + drug<br />
**[[3v08]], [[4f5t]], [[4f5u]], [[5hoz]] – hoSA – horse<br />
**[[3v08]], [[4f5t]], [[4f5u]], [[5hoz]] – hoSA – horse<br />
 +
**[[6mdq]] – hoSA + testosterone<br />
 +
**[[4j2v]] – hoSA + diiodosalicilate<br />
 +
**[[4ot2]], [[5dqf]], [[5dby]], [[4zbr]], [[4zbq]], [[5v0v]], [[6ci6]] – hoSA + drug<br />
**[[3v09]], [[4f5v]] – rSA – rabbit<br />
**[[3v09]], [[4f5v]] – rSA – rabbit<br />
 +
**[[4po0]] – rSA + drug<br />
**[[4luf]], [[5orf]] – sSA – sheep<br />
**[[4luf]], [[5orf]] – sSA – sheep<br />
 +
**[[4luh]] – sSA + diiodosalicilate<br />
**[[5ori]], [[5otb]] – gSA – goat<br />
**[[5ori]], [[5otb]] – gSA – goat<br />
 +
**[[5osw]] – gSA + diiodosalicilate<br />
**[[3vvj]] – SA – emu<br />
**[[3vvj]] – SA – emu<br />
**[[5ghk]] – SA – dog<br />
**[[5ghk]] – SA – dog<br />
-
**[[4j2v]] – hoSA + diiodosalicilate<br />
+
**[[5yxe]] – SA - cat<br />
-
**[[4jk4]] – bSA + diiodosalicilate<br />
+
-
**[[4luh]] – sSA + diiodosalicilate<br />
+
-
**[[5osw]] – gSA + diiodosalicilate<br />
+
-
**[[4or0]] – bSA + drug<br />
+
-
**[[4ot2]], [[5dqf]], [[5dby]], [[4zbr]], [[4zbq]], [[5v0v]], [[6ci6]] – hoSA + drug<br />
+
-
**[[4po0]] – rSA + drug<br />
+
-
 
+
*Albumin
*Albumin
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**[[3lp9]] – Alb hemopexin domain – ''Lathyrus sativus''<br />
**[[3lp9]] – Alb hemopexin domain – ''Lathyrus sativus''<br />
**[[2lvf]] – Alb – Brazil nut<br />
**[[2lvf]] – Alb – Brazil nut<br />
-
**[[5dom]] – SA 2S – horseradish tree<br />
+
**[[5dom]] – Alb 2S – horseradish tree<br />
**[[5okl]] – ha-Alb<br />
**[[5okl]] – ha-Alb<br />
 +
**[[6fak]] – h-α-Alb<br />
}}
}}
'''References'''
'''References'''
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:44, 4 March 2019

Human serum albumin (PDB code 1bm0)

Drag the structure with the mouse to rotate

3D Structures of albumin

Updated on 04-March-2019

References

  1. ↑ Liu Y, Chen M, Luo Z, Lin J, Song L. Investigation on the site-selective binding of bovine serum albumin by erlotinib hydrochloride. J Biomol Struct Dyn. 2012 Oct 17. PMID:23072300 doi:10.1080/07391102.2012.726532

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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