6h3x
From Proteopedia
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==Oropouche Virus Glycoprotein Gc Head Domain== | ==Oropouche Virus Glycoprotein Gc Head Domain== | ||
| - | <StructureSection load='6h3x' size='340' side='right' caption='[[6h3x]], [[Resolution|resolution]] 2.09Å' scene=''> | + | <StructureSection load='6h3x' size='340' side='right' caption='[[6h3x]], [[Resolution|resolution]] 2.09Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6h3x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H3X FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6h3x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oropouche_virus Oropouche virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H3X FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h3x OCA], [http://pdbe.org/6h3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h3x RCSB], [http://www.ebi.ac.uk/pdbsum/6h3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h3x ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h3x OCA], [http://pdbe.org/6h3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h3x RCSB], [http://www.ebi.ac.uk/pdbsum/6h3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h3x ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Orthobunyaviruses (OBVs) form a distinct genus of arthropod-borne bunyaviruses that can cause severe disease upon zoonotic transmission to humans. Antigenic drift or genome segment re-assortment have in the past resulted in new pathogenic OBVs, making them potential candidates for causing emerging zoonoses in the future. Low-resolution electron cryo-tomography studies have shown that OBV particles feature prominent trimeric spikes, but their molecular organization remained unknown. Here we report X-ray crystallography studies of four different OBVs showing that the spikes are formed by an N-terminal extension of the fusion glycoprotein Gc. Using Schmallenberg virus, a recently emerged OBV, we also show that the projecting spike is the major target of the neutralizing antibody response, and provide X-ray structures in complex with two protecting antibodies. We further show that immunization of mice with the spike domains elicits virtually sterilizing immunity, providing fundamental knowledge essential in the preparation for potential newly emerging OBV zoonoses. | ||
| + | |||
| + | Orthobunyavirus spike architecture and recognition by neutralizing antibodies.,Hellert J, Aebischer A, Wernike K, Haouz A, Brocchi E, Reiche S, Guardado-Calvo P, Beer M, Rey FA Nat Commun. 2019 Feb 20;10(1):879. doi: 10.1038/s41467-019-08832-8. PMID:30787296<ref>PMID:30787296</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6h3x" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Oropouche virus]] | ||
[[Category: Aebischer, A]] | [[Category: Aebischer, A]] | ||
[[Category: Beer, M]] | [[Category: Beer, M]] | ||
Revision as of 08:25, 6 March 2019
Oropouche Virus Glycoprotein Gc Head Domain
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