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Ankyrin

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Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <ref>PMID:12456646</ref> <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]]. <ref>PMID:12461176</ref>
Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The '''ankyrin repeat''' is a protein-protein interaction motif. It is a 33 residue segment consisting of a helix-loop-helix motif. The long ankyrin repeat in human ankyrin-R contains 12 ankyrin repeats (residues 402-827) and is called D34 region. <scene name='45/454440/Cv/2'>Click here to see 12 ankyrin repeats</scene>. <ref>PMID:12456646</ref> <scene name='45/454440/Cv/3'>One ankyrin repeat</scene> from [[1n0r]]. <ref>PMID:12461176</ref>
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== 3D Structures of ankyrin ==
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[[Ankyrin 3D structures]]
</StructureSection>
</StructureSection>
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== 3D Structures of Ankyrin ==
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== 3D Structures of ankyrin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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*Ankyrin
*Ankyrin
-
**[[1n11]] – hANK-1 D34 region – human<br />
+
**[[3so8]] – hANK-1 residues 149-310 - human<br />
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**[[2yqf]], [[2yvi]] – hANK-1 death domain – NMR<br />
+
**[[1n11]] – hANK-1 D34 region 402-827<br />
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**[[3f59]] – hANK-1 spectrin-binding domain<br />
+
**[[2yqf]], [[2yvi]] – hANK-1 death domain 1394-1497 – NMR<br />
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**[[3ud1]], [[3ud2]] - hANK-1 zu5a-zu5b domains<br />
+
**[[3f59]] – hANK-1 spectrin-binding domain 911-1068<br />
-
**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains<br />
+
**[[3ud1]], [[3ud2]] - hANK-1 zu5a-zu5b domains 911-1233<br />
-
**[[4o6x]] - hANK-3 death domain<br />
+
**[[4d8o]] - hANK-1 zu5a-zu5b-upa-dd domains 966-1535<br />
**[[4rlv]] - hANK-1 + hANK-2<br />
**[[4rlv]] - hANK-1 + hANK-2<br />
**[[5y4d]] - hANK-1/hANK-2<br />
**[[5y4d]] - hANK-1/hANK-2<br />
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**[[5yre]] - hANK-2 residues 264-483, 857-896<br />
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**[[5y4e]] - hANK-2 residues 264-483, 857-896<br />
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**[[5yrf]] - hANK-2 residues 430-873<br />
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**[[5y4f]] - hANK-2 residues 430-873<br />
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**[[3so8]] – hANK-A residues 149-310<br />
+
**[[4o6x]] - hANK-3 death domain<br />
**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />
**[[1n0q]], [[1n0r]], [[2bkg]], [[2qyj]] – dANK repeats – designed<br />
**[[2aja]] – LpANK – ''Legionella pneumophila''<br />
**[[2aja]] – LpANK – ''Legionella pneumophila''<br />
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**[[5k34]] – LpANK B <br />
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**[[5k34]] – LpANK-2 <br />
**[[3hra]] – ANK – ''Enterococus faecalis''<br />
**[[3hra]] – ANK – ''Enterococus faecalis''<br />
**[[4tum]] – ANK-2 - ''Arabidopsis thaliana'' <br />
**[[4tum]] – ANK-2 - ''Arabidopsis thaliana'' <br />
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*Ankyrin complexes
*Ankyrin complexes
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**[[3kbt]], [[3kbu]] - hANK-1 residues 911-1068 + spectrin β chain<br />
+
**[[3kbt]], [[3kbu]] - hANK-1 spectrin-binding domain + spectrin β chain<br />
**[[4qqi]] - hANK-2 + RFX7<br />
**[[4qqi]] - hANK-2 + RFX7<br />
**[[4lg6]] - hANK-2 + CCDC-8<br />
**[[4lg6]] - hANK-2 + CCDC-8<br />
**[[1svx]] – dANK + maltose-binding protein<br />
**[[1svx]] – dANK + maltose-binding protein<br />
**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />
**[[3noc]], [[3nog]] – dANK + acriflavine resistance protein B<br />
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**[[5k35]] – LpANK B + SKP1<br />
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**[[5k35]] – LpANK-2 + SKP1<br />
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**[[4zhb]] – LpANK B N-terminal + peptide<br />
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**[[4zhb]] – LpANK-2 N-terminal + peptide<br />
**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />
**[[3q9u]], [[3q9n]] – ANK + COA-binding protein – ''Escherichia coli''<br />

Revision as of 10:33, 6 March 2019

Human ankyrin-1 ankyrin repeat region (containing 12 repeats) complex with Cl- (green) and Br- (dark red) ions 1n11

Drag the structure with the mouse to rotate

3D Structures of ankyrin

Updated on 06-March-2019

References

  1. ↑ Michaely P, Tomchick DR, Machius M, Anderson RG. Crystal structure of a 12 ANK repeat stack from human ankyrinR. EMBO J. 2002 Dec 2;21(23):6387-96. PMID:12456646
  2. ↑ Mosavi LK, Minor DL Jr, Peng ZY. Consensus-derived structural determinants of the ankyrin repeat motif. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16029-34. Epub 2002 Dec 2. PMID:12461176 doi:http://dx.doi.org/10.1073/pnas.252537899

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Michal Harel, Alexander Berchansky, Narendra Kumar Verma

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