Dual specificity protein kinase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The dual specificity protein kinase '''TTK''' or '''monopolar spindle kinase 1''' contains tetratricopeptide repeat domain (TPR) which serves as interaction domain between proteins. The TPR domain is a helical 34 amino acid motif which is found in several copies in a protein which fold together forming a protein-protein binding domain. Cancer therapy potential drugs bind in <scene name='46/468134/Cv/ | + | The dual specificity protein kinase '''TTK''' or '''monopolar spindle kinase 1''' contains tetratricopeptide repeat domain (TPR) which serves as interaction domain between proteins. The TPR domain is a helical 34 amino acid motif which is found in several copies in a protein which fold together forming a protein-protein binding domain. Cancer therapy potential drugs bind in <scene name='46/468134/Cv/3'>TTK active site</scene>.<ref>PMID:9779990</ref><ref>PMID:21159646</ref> |
</StructureSection> | </StructureSection> | ||
==3D structures of dual specificity protein kinase== | ==3D structures of dual specificity protein kinase== | ||
Revision as of 10:50, 10 March 2019
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3D structures of dual specificity protein kinase
Updated on 10-March-2019
References
- ↑ Dhanasekaran N, Premkumar Reddy E. Signaling by dual specificity kinases. Oncogene. 1998 Sep 17;17(11 Reviews):1447-55. PMID:9779990 doi:http://dx.doi.org/10.1038/sj.onc.1202251
- ↑ Colombo R, Caldarelli M, Mennecozzi M, Giorgini ML, Sola F, Cappella P, Perrera C, Depaolini SR, Rusconi L, Cucchi U, Avanzi N, Bertrand JA, Bossi RT, Pesenti E, Galvani A, Isacchi A, Colotta F, Donati D, Moll J. Targeting the Mitotic Checkpoint for Cancer Therapy with NMS-P715, an Inhibitor of MPS1 Kinase. Cancer Res. 2010 Dec 15;70(24):10255-64. PMID:21159646 doi:10.1158/0008-5472.CAN-10-2101
