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Ephrin receptor

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EPHR domains include an ectodomain (residues 23-435) containing the LBD (residues 23-326), a second fibronectin III domain (fn3) (residues 446-539), a transmembrane domain (residues 539-563), a kinase domain (residues 596-900) and a sterile-α-motif (SAM) domain (residues 908-972).
EPHR domains include an ectodomain (residues 23-435) containing the LBD (residues 23-326), a second fibronectin III domain (fn3) (residues 446-539), a transmembrane domain (residues 539-563), a kinase domain (residues 596-900) and a sterile-α-motif (SAM) domain (residues 908-972).
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<scene name='45/450911/Cv/3'>Ephrin A3 receptor with peptide substrate, nucleotide derivative and Mg+2 ion</scene>.
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<scene name='45/450911/Cv/8'>Ephrin A3 receptor with peptide substrate, nucleotide derivative and Mg+2 ion</scene>. Water molecules are shown as red spheres.
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<scene name='45/450911/Cv/6'>Nucleotide derivative and Mg+2 ion binding site</scene>.
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<scene name='45/450911/Cv/9'>Nucleotide derivative and Mg+2 ion binding site</scene>.
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<scene name='45/450911/Cv/7'>Peptide substrate binding site</scene> ([[3fxx]]).<ref>PMID:19678838</ref>
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<scene name='45/450911/Cv/10'>Peptide substrate binding site</scene> ([[3fxx]]).<ref>PMID:19678838</ref>
</StructureSection>
</StructureSection>
== 3D Structures of ephrin receptors ==
== 3D Structures of ephrin receptors ==

Revision as of 09:44, 11 March 2019

Human ephrin A3 receptor (magenta) complex with peptide substrate (green), nucleotide derivative and Mg+2 ion 3fxx

Drag the structure with the mouse to rotate

3D Structures of ephrin receptors

Updated on 11-March-2019


References

  1. ↑ Pitulescu ME, Adams RH. Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev. 2010 Nov 15;24(22):2480-92. doi: 10.1101/gad.1973910. PMID:21078817 doi:http://dx.doi.org/10.1101/gad.1973910
  2. ↑ Genander M, Frisen J. Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol. 2010 Oct;22(5):611-6. doi: 10.1016/j.ceb.2010.08.005. PMID:20810264 doi:http://dx.doi.org/10.1016/j.ceb.2010.08.005
  3. ↑ Davis TL, Walker JR, Allali-Hassani A, Parker SA, Turk BE, Dhe-Paganon S. Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases. FEBS J. 2009 Aug;276(16):4395-404. PMID:19678838 doi:http://dx.doi.org/10.1111/j.1742-4658.2009.07147.x

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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