Anthrax edema factor
From Proteopedia
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== Function == | == Function == | ||
| - | '''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The full anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. The binding of calmodulin to EF changes it from its non-active form to the active one.<ref>PMID:15680766</ref> | + | '''Anthrax edema factor''' (EF) or '''calmodulin-sensitive adenylate cyclase''' is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The full anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. The binding of calmodulin to EF changes it from its non-active form to the active one.<ref>PMID:15680766</ref> |
== Disease == | == Disease == | ||
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*<scene name='48/485623/Cv/2'>EF trimer with 3 calmodulin molecules</scene>. | *<scene name='48/485623/Cv/2'>EF trimer with 3 calmodulin molecules</scene>. | ||
*<scene name='48/485623/Cv/5'>ADP derivative/Yt+3 binding site</scene> of EF. Water molecules are shown as red spheres. | *<scene name='48/485623/Cv/5'>ADP derivative/Yt+3 binding site</scene> of EF. Water molecules are shown as red spheres. | ||
| - | *<scene name='48/485623/Cv/6'>Ca+2 binding site</scene> of calmodulin (PDB code [[1pk0]]).<ref>PMID:14978283</ref> | + | *<scene name='48/485623/Cv/6'>Ca+2 binding site</scene> of calmodulin (PDB code [[1pk0]]).<ref>PMID:14978283</ref> |
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| + | ==3D structures of anthrax edema factor== | ||
| + | [[Anthrax edema factor 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | [[1k8t]] - EF adenylate cyclase domain<br /> | ||
| + | [[1k93]] - EF adenylate cyclase domain + calmodulin <br /> | ||
| + | [[1k90]] - EF adenylate cyclase domain + calmodulin + deoxy-ATP <br /> | ||
[[1lvc]] – EF adenylate cyclase domain C terminal + calmodulin + anthraniloyl-deoxy-ATP<br /> | [[1lvc]] – EF adenylate cyclase domain C terminal + calmodulin + anthraniloyl-deoxy-ATP<br /> | ||
[[1pk0]] - EF adenylate cyclase domain C terminal + calmodulin + phosphonylmethoxyethyl-ADP<br /> | [[1pk0]] - EF adenylate cyclase domain C terminal + calmodulin + phosphonylmethoxyethyl-ADP<br /> | ||
Revision as of 09:35, 12 March 2019
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3D structures of anthrax edema factor
Updated on 12-March-2019
1k8t - EF adenylate cyclase domain
1k93 - EF adenylate cyclase domain + calmodulin
1k90 - EF adenylate cyclase domain + calmodulin + deoxy-ATP
1lvc – EF adenylate cyclase domain C terminal + calmodulin + anthraniloyl-deoxy-ATP
1pk0 - EF adenylate cyclase domain C terminal + calmodulin + phosphonylmethoxyethyl-ADP
1s26 - EF adenylate cyclase domain C terminal + calmodulin + methylene-ATP
1sk6 - EF adenylate cyclase domain C terminal + calmodulin + pyrophosphate + cAMP
1xfu - EF (mutant) + calmodulin
1xfv - EF + calmodulin + deoxy-ATP
1xfw - EF + calmodulin + cAMP
1xfx, 1xfy, 1xfz - EF + calmodulin
References
- ↑ Abrami L, Reig N, van der Goot FG. Anthrax toxin: the long and winding road that leads to the kill. Trends Microbiol. 2005 Feb;13(2):72-8. PMID:15680766 doi:http://dx.doi.org/10.1016/j.tim.2004.12.004
- ↑ Shen Y, Zhukovskaya NL, Zimmer MI, Soelaiman S, Bergson P, Wang CR, Gibbs CS, Tang WJ. Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3242-7. Epub 2004 Feb 20. PMID:14978283 doi:10.1073/pnas.0306552101
