ERGIC-53

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Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus<ref>PMID:24237698</ref>.
Some ER storage diseases have relationship with ERGIC-53. ERGIC-53 is required for the propagation of arenavirus, coronavirus and filovirus<ref>PMID:24237698</ref>.
== Structural highlights ==
== Structural highlights ==
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ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The <scene name='74/748868/Cv/2'>mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well</scene><ref>PMID:23709226</ref>.
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ERGIC-53 contains an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain (CRD), a stalk region, a transmembrane domain and a short cytoplasmic domain. The <scene name='74/748868/Cv/3'>mannose-binding pocket of ERGIC-53 contains a Ca+2 ion as well</scene><ref>PMID:23709226</ref>.
</StructureSection>
</StructureSection>
==3D structures of ERGIC-53==
==3D structures of ERGIC-53==

Revision as of 11:48, 13 March 2019

Human ERGIC-53 carbohydrate recognition domain complex with mannose (stick model), glycerol and Ca+2 ion (green) (PDB code 4gky)

Drag the structure with the mouse to rotate

3D structures of ERGIC-53

Updated on 13-March-2019

4ygb, 4ygc, 4ygd, 4yge, 3wht, 3lcp, 3a4u – hERGIC-53 CRD domain + MCFD2 + Ca - human
3whu, 3wnx – hERGIC-53 CRD domain + MCFD2 + Ca + mannose
4gkx – hERGIC-53 CRD domain + Ca
4gky – hERGIC-53 CRD domain + Ca + mannose
1r1z – rERGIC-53 CRD domain + Ca - rat
1gv9 – rERGIC-53 CRD domain

References

  1. ↑ Zhang YC, Zhou Y, Yang CZ, Xiong DS. A review of ERGIC-53: its structure, functions, regulation and relations with diseases. Histol Histopathol. 2009 Sep;24(9):1193-204. PMID:19609866
  2. ↑ Klaus JP, Eisenhauer P, Russo J, Mason AB, Do D, King B, Taatjes D, Cornillez-Ty C, Boyson JE, Thali M, Zheng C, Liao L, Yates JR 3rd, Zhang B, Ballif BA, Botten JW. The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles. Cell Host Microbe. 2013 Nov 13;14(5):522-34. doi: 10.1016/j.chom.2013.10.010. PMID:24237698 doi:http://dx.doi.org/10.1016/j.chom.2013.10.010
  3. ↑ Zheng C, Page RC, Das V, Nix JC, Wigren E, Misra S, Zhang B. Structural characterization of carbohydrate binding by LMAN1 provides new insight into the endoplasmic reticulum export of FV and FVIII. J Biol Chem. 2013 May 24. PMID:23709226 doi:10.1074/jbc.M113.461434

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