6a68

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'''Unreleased structure'''
 
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The entry 6a68 is ON HOLD until Paper Publication
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==the crystal structure of rat calcium-dependent activator protein for secretion (CAPS) DAMH domain==
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<StructureSection load='6a68' size='340' side='right'caption='[[6a68]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6a68]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A68 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a68 OCA], [http://pdbe.org/6a68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a68 RCSB], [http://www.ebi.ac.uk/pdbsum/6a68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a68 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CAPS1_RAT CAPS1_RAT]] Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.<ref>PMID:10792045</ref> <ref>PMID:1516133</ref> <ref>PMID:15312653</ref> <ref>PMID:9162085</ref> <ref>PMID:9697858</ref> <ref>PMID:9697859</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Ma, C]]
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[[Category: Wei, Z Q]]
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[[Category: Yao, D Q]]
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[[Category: Zhang, R G]]
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[[Category: Zhou, H]]
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[[Category: Exocytosis]]
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[[Category: Exocytosis dcv transition]]

Revision as of 11:53, 13 March 2019

the crystal structure of rat calcium-dependent activator protein for secretion (CAPS) DAMH domain

PDB ID 6a68

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