6fqg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6fqg" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6fqg is ON HOLD until Paper Publication
+
==GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution==
-
 
+
<StructureSection load='6fqg' size='340' side='right'caption='[[6fqg]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
-
Authors: Coombs, I.D., Soto, D., Gold, M.G., Farrant, M.F., Cull-Candy, S.G.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6fqg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FQG FirstGlance]. <br>
-
Description: GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GGL:GAMMA-L-GLUTAMIC+ACID'>GGL</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fqg OCA], [http://pdbe.org/6fqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fqg RCSB], [http://www.ebi.ac.uk/pdbsum/6fqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fqg ProSAT]</span></td></tr>
-
[[Category: Gold, M.G]]
+
</table>
-
[[Category: Cull-Candy, S.G]]
+
== Function ==
-
[[Category: Farrant, M.F]]
+
[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Coombs, I D]]
 +
[[Category: Cull-Candy, S G]]
 +
[[Category: Farrant, M F]]
 +
[[Category: Gold, M G]]
[[Category: Soto, D]]
[[Category: Soto, D]]
-
[[Category: Coombs, I.D]]
+
[[Category: Ampar receptor]]
 +
[[Category: Competitive antagonist]]
 +
[[Category: Cross-linked dimer]]
 +
[[Category: Ligand binding domain]]
 +
[[Category: Membrane protein]]

Revision as of 11:59, 13 March 2019

GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution

PDB ID 6fqg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6fqg"
Personal tools