6igx
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human CAP-G in complex with CAP-H== | |
| - | + | <StructureSection load='6igx' size='340' side='right'caption='[[6igx]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6igx]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IGX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IGX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6igx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6igx OCA], [http://pdbe.org/6igx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6igx RCSB], [http://www.ebi.ac.uk/pdbsum/6igx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6igx ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CND2_HUMAN CND2_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CND3_HUMAN CND3_HUMAN]] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.<ref>PMID:11136719</ref> [[http://www.uniprot.org/uniprot/CND2_HUMAN CND2_HUMAN]] Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).<ref>PMID:11136719</ref> <ref>PMID:27737959</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hara, K]] | ||
| + | [[Category: Hashimoto, H]] | ||
| + | [[Category: Migita, T]] | ||
| + | [[Category: Shimizu, K]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Chromosome condensation]] | ||
| + | [[Category: Condensin i subunit]] | ||
| + | [[Category: Heat repeat]] | ||
| + | [[Category: Protein-protein interaction]] | ||
Revision as of 12:04, 13 March 2019
Crystal structure of human CAP-G in complex with CAP-H
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