6nr3
From Proteopedia
(Difference between revisions)
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==Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium== | ==Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium== | ||
| - | <StructureSection load='6nr3' size='340' side='right' caption='[[6nr3]], [[Resolution|resolution]] 3.40Å' scene=''> | + | <StructureSection load='6nr3' size='340' side='right'caption='[[6nr3]], [[Resolution|resolution]] 3.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6nr3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NR3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NR3 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6nr3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Collared_flycatcher Collared flycatcher]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NR3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NR3 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KX7:Icilin'>KX7</scene>, <scene name='pdbligand=KXP:(2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl+icosa-5,8,11,14-tetraenoate'>KXP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KX7:Icilin'>KX7</scene>, <scene name='pdbligand=KXP:(2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl+icosa-5,8,11,14-tetraenoate'>KXP</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRPM8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=59894 Collared flycatcher])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nr3 OCA], [http://pdbe.org/6nr3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nr3 RCSB], [http://www.ebi.ac.uk/pdbsum/6nr3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nr3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nr3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nr3 OCA], [http://pdbe.org/6nr3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nr3 RCSB], [http://www.ebi.ac.uk/pdbsum/6nr3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nr3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Collared flycatcher]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Borgnia, M J]] | [[Category: Borgnia, M J]] | ||
[[Category: Hsu, A L]] | [[Category: Hsu, A L]] | ||
Revision as of 12:49, 13 March 2019
Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium
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Categories: Collared flycatcher | Large Structures | Borgnia, M J | Hsu, A L | Le, S C | Lee, S Y | Yang, H | Yin, Y | Calcium-permeable ion channel | Cold sensing | Cooling agent | Icilin | Ion channel | Lipid sensing | Membrane protein | Menthol | Transport protein | Trp channel | Trpm channel | Trpm8 channel | Ws-12
