F-actin capping protein

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'''F-actin capping protein''' (CapZ) regulates growth of actin filaments by capping the barbed end of the growing filament thus blocking the exchange of subunits at this end. <scene name='50/508421/Cv/2'>CapZ is a heterodimer with α and β subunits</scene>. <scene name='50/508421/Cv/3'>Ba+2 ion coordination site</scene> in CapZ (PDB code [[3aa7]])<ref>PMID:20625546</ref>, water molecules are shown as red sphesres. For more details see [[Group:MUZIC:CapZ]].
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'''F-actin capping protein''' (CapZ) regulates growth of actin filaments by capping the barbed end of the growing filament thus blocking the exchange of subunits at this end. <scene name='50/508421/Cv/4'>CapZ is a heterodimer with α and β subunits</scene>. <scene name='50/508421/Cv/5'>Ba+2 ion coordination site</scene> in CapZ (PDB code [[3aa7]])<ref>PMID:20625546</ref>, water molecules are shown as red sphesres. For more details see [[Group:MUZIC:CapZ]].
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Revision as of 11:20, 14 March 2019

F-actin capping protein α (cyan) and β subunits (magenta) complex with ethanosulfonic acid and Ba+2 ion (PDB code 3aa7)

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3D structures of F-actin capping protein

Updated on 14-March-2019

1izn – cCapZ α1+β – chicken
3aa7 - cCapZ α1+β (mutant)
2kbm - CapZ α2 + S-100 calcium-binding protein - rat
3lk2, 3lk3 - cCapZ α1+β + leucine-rich repeat-containing protein 16A
3aa0 - cCapZ α1+β (mutant) + leucine-rich repeat-containing protein 16A peptide
3aae - cCapZ α1+β + leucine-rich repeat-containing protein 16A peptide
3aa1 - cCapZ α1+β (mutant) + CKIP-1 peptide
2kz7 - cCapZ α1+β + leucine-rich repeat-containing protein 16A]] - NMR
3lk4 - cCapZ α1+β + CD2-associated protein
3aa6 - cCapZ α1+β (mutant) + CD2-associated protein peptide
2kxp - cCapZ α1+β + myotrophin – NMR
3aaa - cCapZ α1+β + myotrophin
4akr - CAPZ α1+β – slime mold

References

  1. ↑ Takeda S, Minakata S, Koike R, Kawahata I, Narita A, Kitazawa M, Ota M, Yamakuni T, Maeda Y, Nitanai Y. Two distinct mechanisms for actin capping protein regulation--steric and allosteric inhibition. PLoS Biol. 2010 Jul 6;8(7):e1000416. PMID:20625546 doi:10.1371/journal.pbio.1000416

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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