Antigen 85
From Proteopedia
(Difference between revisions)
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The 3D structures of the 3 antigens show that their active sites are virtually identical indicating that they share the same substrate. However, residues at the surface of the enzymes are different. | The 3D structures of the 3 antigens show that their active sites are virtually identical indicating that they share the same substrate. However, residues at the surface of the enzymes are different. | ||
*<scene name='70/706736/Cv/5'>Click here to see active site</scene>.<ref>PMID:15192106</ref> | *<scene name='70/706736/Cv/5'>Click here to see active site</scene>.<ref>PMID:15192106</ref> | ||
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| + | == 3D Structures of antigen 85 == | ||
| + | [[Antigen 85 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
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**[[4mql]], [[4qdx]], [[4qdz]], [[4qe3]], [[4qek]] – Mt85C (mutant)<br /> | **[[4mql]], [[4qdx]], [[4qdz]], [[4qe3]], [[4qek]] – Mt85C (mutant)<br /> | ||
**[[1dqy]] – Mt85C + diethyl phosphate inhibitor <br /> | **[[1dqy]] – Mt85C + diethyl phosphate inhibitor <br /> | ||
| - | **[[4mqm]], [[4qdu]] – Mt85C + ebselen inhibitor <br /> | + | **[[4mqm]], [[4qdu]], [[5kwi]], [[5kwj]] – Mt85C + ebselen inhibitor <br /> |
**[[4qdo]] – Mt85C + chloromercurybenzoate inhibitor <br /> | **[[4qdo]] – Mt85C + chloromercurybenzoate inhibitor <br /> | ||
**[[4qdt]] – Mt85C + iodoacetamide inhibitor <br /> | **[[4qdt]] – Mt85C + iodoacetamide inhibitor <br /> | ||
| + | **[[5ocj]] – Mt85C + cyclophostin inhibitor<br /> | ||
**[[1va5]] – Mt85C + octyl glucoside <br /> | **[[1va5]] – Mt85C + octyl glucoside <br /> | ||
**[[3hrh]] – Mt85C + glycerol <br /> | **[[3hrh]] – Mt85C + glycerol <br /> | ||
| + | **[[5vns]] – Mt85C + tetrahydrolipstatin <br /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:51, 18 March 2019
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3D Structures of antigen 85
Updated on 18-March-2019
References
- ↑ Ronning DR, Vissa V, Besra GS, Belisle JT, Sacchettini JC. Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity. J Biol Chem. 2004 Aug 27;279(35):36771-7. Epub 2004 Jun 10. PMID:15192106 doi:http://dx.doi.org/10.1074/jbc.M400811200
