5zhq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Scylla paramamosain arginine kinase== | |
| + | <StructureSection load='5zhq' size='340' side='right'caption='[[5zhq]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5zhq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Scylla_paramamosain Scylla paramamosain]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZHQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zhq OCA], [http://pdbe.org/5zhq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zhq RCSB], [http://www.ebi.ac.uk/pdbsum/5zhq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zhq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Shellfish are one of the most common causes of food allergy. Arginine kinase (AK) is known as an important allergen in shellfish. In the present study, AK from crab (Scylla paramamosain) was purified and its crystal structure was determined. A comparison of AK from S. paramamosain to AKs of other species showed high amino acid sequence and secondary structure identity, while the superposition of crystal structures of AKs from different species revealed only slight differences. Similarity of the linear epitope regions among species was observed in the epitope alignment of AKs; conformational epitopes were located in the regions where secondary structure was conserved. The structure of S. paramamosain AK is an accurate template for the analysis of the IgE binding pattern, and the structure conservation and epitope similarity of AKs among species could help to inform our understanding of the cross-reactivity and contribute to the prediction of cross-reactivity related epitopes. | ||
| - | + | Crystal structure determination of Scylla paramamosain arginine kinase, an allergen that may cause cross-reactivity among invertebrates.,Yang Y, Liu GY, Yang H, Hu MJ, Cao MJ, Su WJ, Jin T, Liu GM Food Chem. 2019 Jan 15;271:597-605. doi: 10.1016/j.foodchem.2018.08.003. Epub, 2018 Aug 2. PMID:30236721<ref>PMID:30236721</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5zhq" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Scylla paramamosain]] | ||
| + | [[Category: Jin, T C]] | ||
| + | [[Category: Liu, G M]] | ||
[[Category: Yang, Y]] | [[Category: Yang, Y]] | ||
| - | [[Category: | + | [[Category: Allergen]] |
| - | [[Category: | + | [[Category: Arginine kinase]] |
| + | [[Category: Food allergy]] | ||
| + | [[Category: Sea food allergy]] | ||
Revision as of 07:40, 20 March 2019
Crystal structure of Scylla paramamosain arginine kinase
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