6aj4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the DHR-2 domain of DOCK7 in complex with Cdc42== | |
| - | + | <StructureSection load='6aj4' size='340' side='right'caption='[[6aj4]], [[Resolution|resolution]] 3.26Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6aj4]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AJ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AJ4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aj4 OCA], [http://pdbe.org/6aj4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aj4 RCSB], [http://www.ebi.ac.uk/pdbsum/6aj4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aj4 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/DOCK7_HUMAN DOCK7_HUMAN]] Early-onset epileptic encephalopathy-cortical blindness-intellectual disability-facial dysmorphism syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DOCK7_HUMAN DOCK7_HUMAN]] Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity).[UniProtKB:Q8R1A4]<ref>PMID:16982419</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Kukimoto-Niino, M]] | ||
| + | [[Category: Shirouzu, M]] | ||
| + | [[Category: Cdc42]] | ||
| + | [[Category: Dhr-2]] | ||
| + | [[Category: Dock]] | ||
| + | [[Category: Gef]] | ||
| + | [[Category: Gtpase]] | ||
| + | [[Category: Rac]] | ||
| + | [[Category: Rho]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 07:45, 20 March 2019
Crystal structure of the DHR-2 domain of DOCK7 in complex with Cdc42
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Categories: Large Structures | Kukimoto-Niino, M | Shirouzu, M | Cdc42 | Dhr-2 | Dock | Gef | Gtpase | Rac | Rho | Signaling protein
