6fw3

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m (Protected "6fw3" [edit=sysop:move=sysop])
Current revision (07:52, 20 March 2019) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6fw3 is ON HOLD until Paper Publication
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==Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-007==
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<StructureSection load='6fw3' size='340' side='right'caption='[[6fw3]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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Authors: Singh, A.K., Brown, D.G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6fw3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FW3 FirstGlance]. <br>
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Description: Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-007
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E8H:1-(2-{4-[(4aS,8aR)-4-(3,4-dimethoxyphenyl)-1-oxo-1,2,4a,5,8,8a-hexahydrophthalazin-2-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione'>E8H</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6fv9|6fv9]], [[6fdi|6fdi]], [[6fds|6fds]], [[6fdw|6fdw]], [[6fdx|6fdx]], [[6fe3|6fe3]], [[6fe7|6fe7]], [[6feb|6feb]], [[6fet|6fet]]</td></tr>
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[[Category: Brown, D.G]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
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[[Category: Singh, A.K]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fw3 OCA], [http://pdbe.org/6fw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fw3 RCSB], [http://www.ebi.ac.uk/pdbsum/6fw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fw3 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[http://omim.org/entry/614613 614613]]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
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[[Category: Large Structures]]
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[[Category: Brown, D G]]
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[[Category: Singh, A K]]
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[[Category: Alternative splicing]]
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[[Category: Camp hydrolysis]]
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[[Category: Hydrolase]]
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[[Category: Phosphodiesterase]]

Current revision

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-007

PDB ID 6fw3

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