6i0r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of quinolinate synthase in complex with 5-mercaptopyridine-2,3-dicarboxylic acid== | |
| + | <StructureSection load='6i0r' size='340' side='right'caption='[[6i0r]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6i0r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I0R FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=H2S:HYDROSULFURIC+ACID'>H2S</scene>, <scene name='pdbligand=QAT:5-mercaptopyridine-2,3-dicarboxylic+acid'>QAT</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6i0k|6i0k]], [[6i0p|6i0p]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Quinolinate_synthase Quinolinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.72 2.5.1.72] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0r OCA], [http://pdbe.org/6i0r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i0r RCSB], [http://www.ebi.ac.uk/pdbsum/6i0r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0r ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NADA_THEMA NADA_THEMA]] Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Quinolinate synthase (NadA) is a [4Fe-4S] cluster-containing enzyme involved in the formation of quinolinic acid, the precursor of the essential NAD coenzyme. Here, we report the synthesis and activity of derivatives of the first inhibitor of NadA. Using multidisciplinary approaches we have investigated their action mechanism and discovered additional specific inhibitors of this enzyme. | ||
| - | + | Design of specific inhibitors of quinolinate synthase based on [4Fe-4S] cluster coordination.,Saez Cabodevilla J, Volbeda A, Hamelin O, Latour JM, Gigarel O, Clemancey M, Darnault C, Reichmann D, Amara P, Fontecilla-Camps JC, Ollagnier de Choudens S Chem Commun (Camb). 2019 Mar 11. doi: 10.1039/c8cc09023h. PMID:30855610<ref>PMID:30855610</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6i0r" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Quinolinate synthase]] | ||
| + | [[Category: Fontecilla-Camps, J C]] | ||
[[Category: Volbeda, A]] | [[Category: Volbeda, A]] | ||
| - | [[Category: | + | [[Category: Iron sulfur cluster]] |
| + | [[Category: Nad biosynthesis]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:57, 20 March 2019
Structure of quinolinate synthase in complex with 5-mercaptopyridine-2,3-dicarboxylic acid
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