5zb2

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==Crystal structure of Rad7 and Elc1 complex in yeast==
==Crystal structure of Rad7 and Elc1 complex in yeast==
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<StructureSection load='5zb2' size='340' side='right' caption='[[5zb2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='5zb2' size='340' side='right'caption='[[5zb2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5zb2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZB2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZB2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5zb2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZB2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZB2 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9FO:3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol'>9FO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9FO:3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol'>9FO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAD7, YJR052W, J1665 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), ELC1, YPL046C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zb2 OCA], [http://pdbe.org/5zb2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zb2 RCSB], [http://www.ebi.ac.uk/pdbsum/5zb2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zb2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zb2 OCA], [http://pdbe.org/5zb2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zb2 RCSB], [http://www.ebi.ac.uk/pdbsum/5zb2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zb2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RAD7_YEAST RAD7_YEAST]] Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. This protein is one of 10 proteins (RAD1, 2,3,4,7,10,14, 16,23 and MMS19) involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.<ref>PMID:10601031</ref> <ref>PMID:15177043</ref> [[http://www.uniprot.org/uniprot/ELOC_YEAST ELOC_YEAST]] Prevents degradation of interacting proteins like PCL6 by the proteasome.<ref>PMID:11864988</ref>
[[http://www.uniprot.org/uniprot/RAD7_YEAST RAD7_YEAST]] Component of the global genome repair (GGR) complex which promotes global genome nucleotide excision repair (GG-NER) which removes DNA damage from nontranscribing DNA. This protein is one of 10 proteins (RAD1, 2,3,4,7,10,14, 16,23 and MMS19) involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.<ref>PMID:10601031</ref> <ref>PMID:15177043</ref> [[http://www.uniprot.org/uniprot/ELOC_YEAST ELOC_YEAST]] Prevents degradation of interacting proteins like PCL6 by the proteasome.<ref>PMID:11864988</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nucleotide excision repair (NER) is a versatile system that deals with various bulky and helix-distorting DNA lesions caused by UV and environmental mutagens. Based on how lesion recognition occurs, NER has been separated into global genome repair (GGR) and transcription-coupled repair (TCR). The yeast Rad7-Rad16 complex is indispensable for the GGR sub-pathway. Rad7-Rad16 binds to UV-damaged DNA in a synergistic fashion with Rad4, the main lesion recognizer, to achieve efficient recognition of lesions. In addition, Rad7-Rad16 associates with Elc1 and Cul3 to form an EloC-Cul-SOCS-box (ECS)-type E3 ubiquitin ligase complex that ubiquitinates Rad4 in response to UV radiation. However, the structure and architecture of the Rad7-Rad16-Elc1-Cul3 complex remain unsolved. Here, we determined the structure of the Rad7-Elc1 complex and revealed key interaction regions responsible for the formation of the Rad7-Rad16-Elc1-Cul3 complex. These results provide new insights into the assembly of the Rad7-Rad16-Elc1-Cul3 complex and structural framework for further studies.
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Crystal structure of the yeast Rad7-Elc1 complex and assembly of the Rad7-Rad16-Elc1-Cul3 complex.,Liu L, Huo Y, Li J, Jiang T DNA Repair (Amst). 2019 Feb 22;77:1-9. doi: 10.1016/j.dnarep.2019.02.012. PMID:30840920<ref>PMID:30840920</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5zb2" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baker's yeast]]
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[[Category: Large Structures]]
[[Category: Huo, Y]]
[[Category: Huo, Y]]
[[Category: Jiang, T]]
[[Category: Jiang, T]]

Revision as of 08:18, 20 March 2019

Crystal structure of Rad7 and Elc1 complex in yeast

PDB ID 5zb2

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