Structural highlights
Publication Abstract from PubMed
Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1 A-resolution, in the post-fusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class-I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat and consideration of glycan dynamics reveals extensive coverage of the underlying protein surface, following virus-host membrane fusion.
Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 post-fusion architecture with extensive glycosylation.,Parsy ML, Harlos K, Huiskonen JT, Bowden TA J Virol. 2013 Sep 18. PMID:24049182[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Parsy ML, Harlos K, Huiskonen JT, Bowden TA. Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 post-fusion architecture with extensive glycosylation. J Virol. 2013 Sep 18. PMID:24049182 doi:10.1128/JVI.02298-13
