Atlastin
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
== Disease == | == Disease == | ||
| - | Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D. | + | Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D. Mutations in ATL-3 affect multiple ER-related pathways<ref>PMID:30666337</ref>. |
== Structural highlights == | == Structural highlights == | ||
*<scene name='59/590828/Cv/6'>GDP/AlF4 binding site</scene> from human atlastin (PDB code [[4ido]]).<ref name="Ad">PMID:23334294</ref> Water molecules shown as red spheres. | *<scene name='59/590828/Cv/6'>GDP/AlF4 binding site</scene> from human atlastin (PDB code [[4ido]]).<ref name="Ad">PMID:23334294</ref> Water molecules shown as red spheres. | ||
| + | |||
| + | ==3D structures of atlastin== | ||
| + | [[Atlastin 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
==3D structures of atlastin== | ==3D structures of atlastin== | ||
| Line 19: | Line 23: | ||
*Atlastin-1 | *Atlastin-1 | ||
| - | **[[3q5d]], [[3q5e]], [[3qnu]], [[3qof]] – hATN cytoplasmic domain + GDP – human<br /> | + | **[[3q5d]], [[3q5e]], [[3qnu]], [[3qof]], [[6b9g]] – hATN cytoplasmic domain + GDP – human<br /> |
**[[6b9d]], [[6b9e]] – hATN cytoplasmic domain (mutant) + GDP <br /> | **[[6b9d]], [[6b9e]] – hATN cytoplasmic domain (mutant) + GDP <br /> | ||
**[[4idn]] – hATN cytoplasmic domain + GNP <br /> | **[[4idn]] – hATN cytoplasmic domain + GNP <br /> | ||
Revision as of 08:44, 25 March 2019
| |||||||||||
3D structures of atlastin
Updated on 25-March-2019
References
- ↑ 1.0 1.1 Byrnes LJ, Singh A, Szeto K, Benvin NM, O'Donnell JP, Zipfel WR, Sondermann H. Structural basis for conformational switching and GTP loading of the large G protein atlastin. EMBO J. 2013 Jan 18. doi: 10.1038/emboj.2012.353. PMID:23334294 doi:http://dx.doi.org/10.1038/emboj.2012.353
- ↑ Behrendt L, Kurth I, Kaether C. A disease causing ATLASTIN 3 mutation affects multiple endoplasmic reticulum-related pathways. Cell Mol Life Sci. 2019 Apr;76(7):1433-1445. doi: 10.1007/s00018-019-03010-x., Epub 2019 Jan 21. PMID:30666337 doi:http://dx.doi.org/10.1007/s00018-019-03010-x
