ATP-citrate synthase

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Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/4'>Binding site of tartrate</scene> of ATP-citrate synthase. Water molecules are shown as red spheres. <scene name='47/477091/Cv/6'>Binding site of ADP and Mg+2 ions</scene>, [[3pff]]. <ref>PMID:22102020</ref>
Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/4'>Binding site of tartrate</scene> of ATP-citrate synthase. Water molecules are shown as red spheres. <scene name='47/477091/Cv/6'>Binding site of ADP and Mg+2 ions</scene>, [[3pff]]. <ref>PMID:22102020</ref>
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== 3D Structures of ATP-citrate synthase ==
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[[ATP-citrate synthase 3D structures]]
</StructureSection>
</StructureSection>

Revision as of 09:02, 25 March 2019

ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), 3pff

Drag the structure with the mouse to rotate

3D Structures of ATP-citrate synthase

Updated on 25-March-2019

3mwd, 5tde – hACS + citrate – human
5tdf, 5tet – hACS + citrate derivative
5teq – hACS N-terminal (mutant) + citrate
5te1 – hACS N-terminal (mutant) + citrate derivative
5tes – hACS + citrate + ADP
5tdm – hACS + citrate derivative + ADP
3mwe – hACS + tartrate
3pff, 5tdz - hACS + tartrate + ADP

References

  1. ↑ Sun T, Hayakawa K, Fraser ME. ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1168-72., Epub 2011 Sep 24. PMID:22102020 doi:10.1107/S1744309111028363

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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