6csv

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'''Unreleased structure'''
 
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The entry 6csv is ON HOLD until Paper Publication
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==The structure of the Cep63-Cep152 heterotetrameric complex==
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<StructureSection load='6csv' size='340' side='right'caption='[[6csv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6csv]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CSV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6CSV FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6csv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6csv OCA], [http://pdbe.org/6csv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6csv RCSB], [http://www.ebi.ac.uk/pdbsum/6csv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6csv ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/CEP63_HUMAN CEP63_HUMAN]] Autosomal recessive primary microcephaly. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/CEP63_HUMAN CEP63_HUMAN]] Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).<ref>PMID:21406398</ref> <ref>PMID:21983783</ref> <ref>PMID:26297806</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The cell is constructed by higher-order structures and organelles through complex interactions among distinct structural constituents. The centrosome is a membraneless organelle composed of two microtubule-derived structures called centrioles and an amorphous mass of pericentriolar material. Super-resolution microscopic analyses in various organisms revealed that diverse pericentriolar material proteins are concentrically localized around a centriole in a highly organized manner. However, the molecular nature underlying these organizations remains unknown. Here we show that two human pericentriolar material scaffolds, Cep63 and Cep152, cooperatively generate a heterotetrameric alpha-helical bundle that functions in conjunction with its neighboring hydrophobic motifs to self-assemble into a higher-order cylindrical architecture capable of recruiting downstream components, including Plk4, a key regulator for centriole duplication. Mutations disrupting the self-assembly abrogate Plk4-mediated centriole duplication. Because pericentriolar material organization is evolutionarily conserved, this work may offer a paradigm for investigating the assembly and function of centrosomal scaffolds in various organisms.
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Authors:
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Molecular architecture of a cylindrical self-assembly at human centrosomes.,Kim TS, Zhang L, Il Ahn J, Meng L, Chen Y, Lee E, Bang JK, Lim JM, Ghirlando R, Fan L, Wang YX, Kim BY, Park JE, Lee KS Nat Commun. 2019 Mar 11;10(1):1151. doi: 10.1038/s41467-019-08838-2. PMID:30858376<ref>PMID:30858376</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 6csv" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Ahn, J I]]
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[[Category: Chen, Y]]
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[[Category: Kim, T S]]
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[[Category: Lee, E]]
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[[Category: Lee, K S]]
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[[Category: Park, J E]]
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[[Category: Zhang, L]]
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[[Category: Cell cycle]]
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[[Category: Centrosome]]
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[[Category: Complex]]
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[[Category: Hydrophobic]]

Revision as of 06:32, 27 March 2019

The structure of the Cep63-Cep152 heterotetrameric complex

PDB ID 6csv

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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