6hip
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of SPF45 UHM bound to HIV-1 Rev ULM== | |
| - | + | <StructureSection load='6hip' size='340' side='right'caption='[[6hip]], [[Resolution|resolution]] 1.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hip]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HIP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hip OCA], [http://pdbe.org/6hip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hip RCSB], [http://www.ebi.ac.uk/pdbsum/6hip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hip ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPF45_HUMAN SPF45_HUMAN]] Splice factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.<ref>PMID:12015979</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Corsini, L]] | [[Category: Corsini, L]] | ||
[[Category: Pabis, M]] | [[Category: Pabis, M]] | ||
[[Category: Sattler, M]] | [[Category: Sattler, M]] | ||
| + | [[Category: Splicing]] | ||
| + | [[Category: Splicing factor]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 06:38, 27 March 2019
Structure of SPF45 UHM bound to HIV-1 Rev ULM
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