This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6hip
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of SPF45 UHM bound to HIV-1 Rev ULM== | |
| - | + | <StructureSection load='6hip' size='340' side='right'caption='[[6hip]], [[Resolution|resolution]] 1.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hip]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HIP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hip OCA], [http://pdbe.org/6hip PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hip RCSB], [http://www.ebi.ac.uk/pdbsum/6hip PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hip ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPF45_HUMAN SPF45_HUMAN]] Splice factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.<ref>PMID:12015979</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Corsini, L]] | [[Category: Corsini, L]] | ||
[[Category: Pabis, M]] | [[Category: Pabis, M]] | ||
[[Category: Sattler, M]] | [[Category: Sattler, M]] | ||
| + | [[Category: Splicing]] | ||
| + | [[Category: Splicing factor]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 06:38, 27 March 2019
Structure of SPF45 UHM bound to HIV-1 Rev ULM
| |||||||||||
