Basic Pancreatic Trypsin Inhibitor

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<scene name='43/430026/Cv/3'>Residue K15 of BPTI</scene> extends into the active site of trypsin and inhibits its proteolytic function. <ref>PMID:10210204</ref>
<scene name='43/430026/Cv/3'>Residue K15 of BPTI</scene> extends into the active site of trypsin and inhibits its proteolytic function. <ref>PMID:10210204</ref>
 +
 +
== 3D Structures of BPTI ==
 +
[[BPTI 3D structures]]
</StructureSection>
</StructureSection>
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* BPTI
* BPTI
-
**[[2zvx]], [[2zjx]], [[1g6x]], [[1qlq]], [[1bti]], [[1fan]], [[1nag]], [[1bpt]], [[7pti]], [[8pti]], [[3aub]], [[3auc]], [[3aud]], [[3aue]], [[3aug]], [[3auh]], [[3aui]], [[5jb4]], [[5jb5]], [[5jb6]], [[5jb7]] – bBPTI (mutant) - bovine<br />
+
**[[2zvx]], [[2zjx]], [[1g6x]], [[1qlq]], [[1bti]], [[1fan]], [[1nag]], [[1bpt]], [[7pti]], [[8pti]], [[3aub]], [[3auc]], [[3aud]], [[3aue]], [[3aug]], [[3auh]], [[3aui]], [[5jb4]], [[5jb5]], [[5jb6]], [[5jb7]], [[5xx2]], [[5xx3]], [[5xx4]], [[5xx5]], [[5xx6]], [[5xx7]], [[5xx8]] – bBPTI (mutant) - bovine<br />
**[[3ci7]] - BPTI (mutant) – synthesized<br />
**[[3ci7]] - BPTI (mutant) – synthesized<br />
-
**[[2by5]], [[2by6]], [[2by7]], [[2by8]], [[2by9]], [[2bya]], [[1k6u]], [[1bhc]], [[1bpi]], [[1b0c]], [[1bz5]], [[2hex]], [[5pti]], [[4pti]], [[9pti]], [[3wny]] - bBPTI<br />
+
**[[2by5]], [[2by6]], [[2by7]], [[2by8]], [[2by9]], [[2bya]], [[1k6u]], [[1bhc]], [[1bpi]], [[1b0c]], [[1bz5]], [[2hex]], [[5pti]], [[4pti]], [[9pti]], [[3wny]], [[6f1f]] - bBPTI<br />
**[[1uua]] – bBPTI truncated – NMR<br />
**[[1uua]] – bBPTI truncated – NMR<br />
**[[1uub]] - bBPTI truncated (mutant) – NMR<br />
**[[1uub]] - bBPTI truncated (mutant) – NMR<br />
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* BPTI+protease
* BPTI+protease
-
**[[3fp6]] – rBPTI+anionic trypsin – rat<br />
+
**[[3fp6]] – bBPTI+anionic trypsin <br />
**[[3tgi]], [[1bzx]] - bBPTI+anionic trypsin<br />
**[[3tgi]], [[1bzx]] - bBPTI+anionic trypsin<br />
**[[2ptc]] – bBPTI + β-trypsin<br />
**[[2ptc]] – bBPTI + β-trypsin<br />
-
**[[1co7]], [[1f5r]], [[1f7z]], [[3tgk]] - rBPTI+anionic trypsin (mutant)<br />
+
**[[1co7]], [[1f5r]], [[1f7z]], [[3tgk]] - bBPTI+anionic trypsin (mutant)<br />
**[[3tgj]] - bBPTI+anionic trypsin (mutant)<br />
**[[3tgj]] - bBPTI+anionic trypsin (mutant)<br />
-
**[[3fp7]], [[3fp8]], [[1fy8]] – rBPTI (mutant) +anionic trypsin<br />
+
**[[3fp7]], [[3fp8]], [[1fy8]] – bBPTI (mutant) +anionic trypsin<br />
**[[2r9p]] – bBPTI+hMesotrypsin (mutant)<br />
**[[2r9p]] – bBPTI+hMesotrypsin (mutant)<br />
**[[3p92]], [[3p95]] – bBPTI (mutant) +hMesotrypsin (mutant)<br />
**[[3p92]], [[3p95]] – bBPTI (mutant) +hMesotrypsin (mutant)<br />
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**[[2ftl]], [[3btk]], [[4y0y]] - bBPTI+bTrypsin cationic <br />
**[[2ftl]], [[3btk]], [[4y0y]] - bBPTI+bTrypsin cationic <br />
**[[1brb]], [[3otj]] - bBPTI+rTrypsin cationic<br />
**[[1brb]], [[3otj]] - bBPTI+rTrypsin cationic<br />
-
**[[4wwy]], [[4wxv]] - bBPTI+ hTrypsin cationic – human<br />
+
**[[4wwy]], [[4wxv]] - bBPTI+ hTrypsin cationic<br />
**[[2ftm]], [[2fi3]], [[2fi5]], [[1ejm]], [[4y0z]], [[4y10]], [[4y11]] – bBPTI (mutant)+bTrypsin cationic<br />
**[[2ftm]], [[2fi3]], [[2fi5]], [[1ejm]], [[4y0z]], [[4y10]], [[4y11]] – bBPTI (mutant)+bTrypsin cationic<br />
**[[3bte]], [[3btq]], [[3btd]], [[3btf]], [[3btg]], [[3bth]], [[3btm]], [[3btt]], [[3btw]], [[1aal]], [[6pti]] - bBPTI (mutant)+bTrypsin<br />
**[[3bte]], [[3btq]], [[3btd]], [[3btf]], [[3btg]], [[3bth]], [[3btm]], [[3btt]], [[3btw]], [[1aal]], [[6pti]] - bBPTI (mutant)+bTrypsin<br />
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**[[1p2m]], [[1p2n]], [[1p2o]], [[1p2q]] - bBPTI (mutant)+bChymotrypsinogen A<br />
**[[1p2m]], [[1p2n]], [[1p2o]], [[1p2q]] - bBPTI (mutant)+bChymotrypsinogen A<br />
**[[1eaw]] – bBPTI+hMatriptase<br />
**[[1eaw]] – bBPTI+hMatriptase<br />
-
**[[1d0d]] – bBPTI+anticoagulant protein – tick<br />
+
**[[1d0d]] – bBPTI+ tick anticoagulant protein<br />
**[[2kai]] – bBPTI + kallikrein A<br />
**[[2kai]] – bBPTI + kallikrein A<br />
**[[3gym]] – bBPTI + prostasin<br />
**[[3gym]] – bBPTI + prostasin<br />
**[[4dg4]] – bBPTI + PRSS3 protein (mutant)<br />
**[[4dg4]] – bBPTI + PRSS3 protein (mutant)<br />
**[[4bnr]] - bBPTI+ hepatopancreas trypsin<br />
**[[4bnr]] - bBPTI+ hepatopancreas trypsin<br />
 +
**[[5yvu]] - bBPTI+ dengue virus NS3<br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 07:34, 2 April 2019

Bovine BPTI (in salmon) complex with trypsin (magenta), sulfate and Ca+2 ion (green) (PDB code 3tgi)

Drag the structure with the mouse to rotate

3D Structures of BPTI

Updated on 02-April-2019

References

  1. ↑ Parkin S, Rupp B, Hope H. Structure of bovine pancreatic trypsin inhibitor at 125 K definition of carboxyl-terminal residues Gly57 and Ala58. Acta Crystallogr D Biol Crystallogr. 1996 Jan 1;52(Pt 1):18-29. PMID:15299722 doi:http://dx.doi.org/10.1107/S0907444995008675
  2. ↑ Pasternak A, Ringe D, Hedstrom L. Comparison of anionic and cationic trypsinogens: the anionic activation domain is more flexible in solution and differs in its mode of BPTI binding in the crystal structure. Protein Sci. 1999 Jan;8(1):253-8. PMID:10210204

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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