User:Emily Leiderman/Sandbox 1

Introduction

The reversible acetylation of lysine residues of histone has been proven to play an important role in the regulation of heterochromatin (inactive) and euchromatin (active). The role of the protein Histone Acetyltransferase is to transfer an acetyl group from Acetyl CoA to a lysine group found on a histone. This results in an increase in gene activity as the addition of acetyl groups to histones results in the formation of euchromatin. In this study we analyzed the structure and function of the HAT1 gene that’s derived from Saccharomyces cerevisiae. We analyzed the various binding sites and interaction mechanisms involved in the acetylation process in addition to the initial Acetyl CoA binding mechanism.

Structure

Domains

Active Site

Hydrophobic Pocket

Mechanism

Protein Gate

Active Residues

Homology to Other Proteins

References

Student Contributors