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6r3k

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m (Protected "6r3k" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6r3k is ON HOLD
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==Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor==
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<StructureSection load='6r3k' size='340' side='right'caption='[[6r3k]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Zak, K.M., Grudnik, P., Skalniak, L., Dubin, G., Holak, T.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6r3k]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5nix 5nix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R3K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R3K FirstGlance]. <br>
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Description: Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQT:(2~{S},4~{R})-1-[[5-chloranyl-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxylic+acid'>JQT</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r3k OCA], [http://pdbe.org/6r3k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r3k RCSB], [http://www.ebi.ac.uk/pdbsum/6r3k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r3k ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Dubin, G]]
[[Category: Grudnik, P]]
[[Category: Grudnik, P]]
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[[Category: Zak, K.M]]
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[[Category: Holak, T A]]
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[[Category: Holak, T.A]]
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[[Category: Dubin, G]]
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[[Category: Skalniak, L]]
[[Category: Skalniak, L]]
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[[Category: Zak, K M]]
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[[Category: Immune checkpoint]]
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[[Category: Immune system]]
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[[Category: Pd-1]]
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[[Category: Pd-l1]]

Revision as of 06:42, 3 April 2019

Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor

PDB ID 6r3k

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