6r3k
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor== | |
| - | + | <StructureSection load='6r3k' size='340' side='right'caption='[[6r3k]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6r3k]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5nix 5nix]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R3K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R3K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JQT:(2~{S},4~{R})-1-[[5-chloranyl-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methyl-phenyl]methoxy]phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxylic+acid'>JQT</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r3k OCA], [http://pdbe.org/6r3k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r3k RCSB], [http://www.ebi.ac.uk/pdbsum/6r3k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r3k ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN]] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dubin, G]] | ||
[[Category: Grudnik, P]] | [[Category: Grudnik, P]] | ||
| - | + | [[Category: Holak, T A]] | |
| - | [[Category: Holak, T | + | |
| - | + | ||
[[Category: Skalniak, L]] | [[Category: Skalniak, L]] | ||
| + | [[Category: Zak, K M]] | ||
| + | [[Category: Immune checkpoint]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Pd-1]] | ||
| + | [[Category: Pd-l1]] | ||
Revision as of 06:42, 3 April 2019
Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor
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Categories: Large Structures | Dubin, G | Grudnik, P | Holak, T A | Skalniak, L | Zak, K M | Immune checkpoint | Immune system | Pd-1 | Pd-l1
