6gdy

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'''Unreleased structure'''
 
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The entry 6gdy is ON HOLD
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==Crystal structure of 2OG oxygenase JMJD6 (aa 1-343) in complex with Fe(II) and 2OG==
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<StructureSection load='6gdy' size='340' side='right'caption='[[6gdy]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
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Authors: Islam, M.S., Schofield, C.J., McDonough, M.A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6gdy]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GDY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GDY FirstGlance]. <br>
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Description: Crystal structure of 2OG oxygenase JMJD6 (aa 1-343) in complex with Fe(II) and 2OG
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gdy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gdy OCA], [http://pdbe.org/6gdy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gdy RCSB], [http://www.ebi.ac.uk/pdbsum/6gdy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gdy ProSAT]</span></td></tr>
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[[Category: Mcdonough, M.A]]
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</table>
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[[Category: Schofield, C.J]]
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== Function ==
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[[Category: Islam, M.S]]
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[[http://www.uniprot.org/uniprot/JMJD6_HUMAN JMJD6_HUMAN]] Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.<ref>PMID:17947579</ref> <ref>PMID:19574390</ref> <ref>PMID:21060799</ref> <ref>PMID:20684070</ref> <ref>PMID:20679243</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Islam, M S]]
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[[Category: McDonough, M A]]
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[[Category: Schofield, C J]]
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[[Category: Arginine demethylase]]
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[[Category: Bi-functional 2og oxygenase]]
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[[Category: Lysyl hydroxylase]]
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[[Category: Oxidoreductase]]

Revision as of 06:56, 3 April 2019

Crystal structure of 2OG oxygenase JMJD6 (aa 1-343) in complex with Fe(II) and 2OG

PDB ID 6gdy

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