6if2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6if2 is ON HOLD until Paper Publication
+
==Complex structure of Rab35 and its effector RUSC2==
-
 
+
<StructureSection load='6if2' size='340' side='right'caption='[[6if2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
Authors: Lin, L., Zhu, J., Zhang, R.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6if2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IF2 FirstGlance]. <br>
-
Description: Complex structure of Rab35 and its effector RUSC2
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6if2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6if2 OCA], [http://pdbe.org/6if2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6if2 RCSB], [http://www.ebi.ac.uk/pdbsum/6if2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6if2 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/RUSC2_HUMAN RUSC2_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/RAB35_HUMAN RAB35_HUMAN]] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth.<ref>PMID:16950109</ref> <ref>PMID:21951725</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Lin, L]]
[[Category: Lin, L]]
 +
[[Category: Zhang, R]]
[[Category: Zhu, J]]
[[Category: Zhu, J]]
-
[[Category: Zhang, R]]
+
[[Category: Complex]]
 +
[[Category: Endocytosis]]
 +
[[Category: Rab35]]
 +
[[Category: Rusc2]]

Revision as of 07:01, 3 April 2019

Complex structure of Rab35 and its effector RUSC2

PDB ID 6if2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6if2"
Personal tools