6bza
From Proteopedia
(Difference between revisions)
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<StructureSection load='6bza' size='340' side='right'caption='[[6bza]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='6bza' size='340' side='right'caption='[[6bza]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6bza]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6bza]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Psef5 Psef5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BZA FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13X:BENZENE-1,3,5-TRIOL'>13X</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=13X:BENZENE-1,3,5-TRIOL'>13X</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pltM, PFL_2784 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=220664 PSEF5])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylhalidase Alkylhalidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.1 3.8.1.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alkylhalidase Alkylhalidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.8.1.1 3.8.1.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bza OCA], [http://pdbe.org/6bza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bza RCSB], [http://www.ebi.ac.uk/pdbsum/6bza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bza ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bza OCA], [http://pdbe.org/6bza PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bza RCSB], [http://www.ebi.ac.uk/pdbsum/6bza PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bza ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Controlled halogenation of chemically versatile substrates is difficult to achieve. Here we describe a unique flavin-dependent halogenase, PltM, which is capable of utilizing a wide range of halides for installation on a diverse array of phenolic compounds, including FDA-approved drugs and natural products, such as terbutaline, fenoterol, resveratrol, and catechin. Crystal structures of PltM in complex with phloroglucinol and FAD in different states yield insight into substrate recognition and the FAD recycling mechanism of this halogenase. | ||
| + | |||
| + | Unusual substrate and halide versatility of phenolic halogenase PltM.,Mori S, Pang AH, Thamban Chandrika N, Garneau-Tsodikova S, Tsodikov OV Nat Commun. 2019 Mar 19;10(1):1255. doi: 10.1038/s41467-019-09215-9. PMID:30890712<ref>PMID:30890712</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6bza" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Alkylhalidase]] | [[Category: Alkylhalidase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Psef5]] | ||
[[Category: Garneau-Tsodikova, S]] | [[Category: Garneau-Tsodikova, S]] | ||
[[Category: Pang, A H]] | [[Category: Pang, A H]] | ||
Revision as of 08:08, 3 April 2019
Crystal structure of halogenase PltM in complex with phloroglucinol and FAD
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