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| - | | + | #REDIRECT [[6oea]] This PDB entry is obsolete and replaced by 6oea |
| - | ==Crystal structure of HMCES SRAP domain in complex with 6-nucleotide 3' overhang DNA==
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| - | <StructureSection load='6nlc' size='340' side='right' caption='[[6nlc]], [[Resolution|resolution]] 2.00Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6nlc]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NLC FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nlc OCA], [http://pdbe.org/6nlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nlc RCSB], [http://www.ebi.ac.uk/pdbsum/6nlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nlc ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN]] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Arrowsmith, C H]]
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| - | [[Category: Bountra, C]]
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| - | [[Category: Edwards, A M]]
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| - | [[Category: Halabelian, L]]
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| - | [[Category: Li, Y]]
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| - | [[Category: Ravichandran, M]]
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| - | [[Category: Structural genomic]]
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| - | [[Category: Zeng, H]]
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| - | [[Category: 3' overhang]]
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| - | [[Category: Dna binding protein-dna complex]]
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| - | [[Category: Dna damage protein]]
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| - | [[Category: Dna-binding]]
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| - | [[Category: Hmce]]
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| - | [[Category: Protein-dna complex]]
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| - | [[Category: Sgc]]
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| - | [[Category: Srap domain]]
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