6jpf

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m (Protected "6jpf" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6jpf is ON HOLD
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==Structure of atOSCA1.1 channel at 3.52A==
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<StructureSection load='6jpf' size='340' side='right'caption='[[6jpf]], [[Resolution|resolution]] 3.52&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6jpf]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5yd1 5yd1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JPF FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5yd1|5yd1]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jpf OCA], [http://pdbe.org/6jpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jpf RCSB], [http://www.ebi.ac.uk/pdbsum/6jpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jpf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/CSCL5_ARATH CSCL5_ARATH]] Acts as a hyperosmolarity-gated non-selective cation channel that permeates Ca(2+) ions. Shows the following permeability sequence: K(+) > Ba(2+) = Ca(2+) > Na(+) = Mg(2+) = Cs(+).<ref>PMID:25162526</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mechanosensitive ion channels convert mechanical stimuli into a flow of ions. These channels are widely distributed from bacteria to higher plants and humans, and are involved in many crucial physiological processes. Here we show that two members of the OSCA protein family in Arabidopsis thaliana, namely AtOSCA1.1 and AtOSCA3.1, belong to a new class of mechanosensitive ion channels. We solve the structure of the AtOSCA1.1 channel at 3.5-A resolution and AtOSCA3.1 at 4.8-A resolution by cryo-electron microscopy. OSCA channels are symmetric dimers that are mediated by cytosolic inter-subunit interactions. Strikingly, they have structural similarity to the mammalian TMEM16 family proteins. Our structural analysis accompanied with electrophysiological studies identifies the ion permeation pathway within each subunit and suggests a conformational change model for activation.
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Authors: Chen, L., Zhang, M., Kang, Y., Wu, J.X.
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Structure of the mechanosensitive OSCA channels.,Zhang M, Wang D, Kang Y, Wu JX, Yao F, Pan C, Yan Z, Song C, Chen L Nat Struct Mol Biol. 2018 Sep;25(9):850-858. doi: 10.1038/s41594-018-0117-6. Epub, 2018 Sep 6. PMID:30190597<ref>PMID:30190597</ref>
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Description: Structure of atOSCA1.1 channel at 3.52A
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Zhang, M]]
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<div class="pdbe-citations 6jpf" style="background-color:#fffaf0;"></div>
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[[Category: Kang, Y]]
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== References ==
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[[Category: Wu, J.X]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Chen, L]]
[[Category: Chen, L]]
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[[Category: Kang, Y]]
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[[Category: Wu, J X]]
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[[Category: Zhang, M]]
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[[Category: Ion channel]]
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[[Category: Mechanosensitive]]
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[[Category: Membrane protein]]
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[[Category: Metal transport]]
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[[Category: Osca]]
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[[Category: Osmosensing]]
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[[Category: Tmem63]]

Revision as of 07:00, 10 April 2019

Structure of atOSCA1.1 channel at 3.52A

PDB ID 6jpf

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