6bdn
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human TAO3 kinase binding ADP== | |
| - | + | <StructureSection load='6bdn' size='340' side='right'caption='[[6bdn]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bdn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BDN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BDN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bdn OCA], [http://pdbe.org/6bdn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bdn RCSB], [http://www.ebi.ac.uk/pdbsum/6bdn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bdn ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TAOK3_HUMAN TAOK3_HUMAN]] Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).<ref>PMID:10559204</ref> <ref>PMID:10924369</ref> <ref>PMID:17396146</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Non-specific serine/threonine protein kinase]] | ||
| + | [[Category: Aleshin, A E]] | ||
| + | [[Category: Bankton, L A]] | ||
| + | [[Category: Courtneidge, S A]] | ||
| + | [[Category: Liddington, R C]] | ||
| + | [[Category: Pinkerton, A]] | ||
| + | [[Category: Adt-binding]] | ||
| + | [[Category: Kinase]] | ||
| + | [[Category: Mapk cascade]] | ||
| + | [[Category: Serine/threonine-protein kinase]] | ||
| + | [[Category: Taok3]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:07, 10 April 2019
Crystal structure of human TAO3 kinase binding ADP
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