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6eb6

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m (Protected "6eb6" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6eb6 is ON HOLD until Paper Publication
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==Crystal structure of BAX W139A monomer==
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<StructureSection load='6eb6' size='340' side='right'caption='[[6eb6]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6eb6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EB6 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6eb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eb6 OCA], [http://pdbe.org/6eb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6eb6 RCSB], [http://www.ebi.ac.uk/pdbsum/6eb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6eb6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Robin, A Y]]
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[[Category: Apoptosis]]
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[[Category: Bax]]
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[[Category: Inactive monomer]]

Revision as of 07:12, 10 April 2019

Crystal structure of BAX W139A monomer

PDB ID 6eb6

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