6g40
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH9525== | |
| - | + | <StructureSection load='6g40' size='340' side='right'caption='[[6g40]], [[Resolution|resolution]] 2.49Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6g40]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G40 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ELK:~{N}-(3-methoxy-4-methyl-phenyl)-4-(4-methoxy-2-oxidanylidene-3~{H}-benzimidazol-1-yl)piperidine-1-carboxamide'>ELK</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g40 OCA], [http://pdbe.org/6g40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g40 RCSB], [http://www.ebi.ac.uk/pdbsum/6g40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g40 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/OGG1_MOUSE OGG1_MOUSE]] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Helleday, T]] | ||
| + | [[Category: Masuyer, G]] | ||
| + | [[Category: Stenmark, P]] | ||
| + | [[Category: Dna binding protein]] | ||
| + | [[Category: Dna lyase]] | ||
| + | [[Category: N-glycosylase]] | ||
Revision as of 07:16, 10 April 2019
Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with ligand TH9525
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