6g5x

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'''Unreleased structure'''
 
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The entry 6g5x is ON HOLD until Paper Publication
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==Crystal Structure of KDM4A with compound YP-02-145==
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<StructureSection load='6g5x' size='340' side='right'caption='[[6g5x]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6g5x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G5X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G5X FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MY7:2-(3-methyl-5-oxidanylidene-4-phenyl-4~{H}-pyrazol-1-yl)-3~{H}-benzimidazole-5-carboxylic+acid'>MY7</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g5x OCA], [http://pdbe.org/6g5x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g5x RCSB], [http://www.ebi.ac.uk/pdbsum/6g5x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g5x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Carter, D M]]
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[[Category: Gohlke, U]]
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[[Category: Heinemann, U]]
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[[Category: Malecki, P H]]
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[[Category: Nazare, M]]
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[[Category: Specker, E]]
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[[Category: Weiss, M S]]
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[[Category: Cancer]]
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[[Category: Drug design]]
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[[Category: Epigenetic]]
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[[Category: Inhibitor design]]
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[[Category: Kdm4a]]
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[[Category: Ligand binding]]
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[[Category: Oxidoreductase]]

Revision as of 07:17, 10 April 2019

Crystal Structure of KDM4A with compound YP-02-145

PDB ID 6g5x

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