6g6l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structures of Human MYC:MAX bHLHZip complex== |
| - | + | <StructureSection load='6g6l' size='340' side='right'caption='[[6g6l]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6g6l]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G6L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G6L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g6l OCA], [http://pdbe.org/6g6l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g6l RCSB], [http://www.ebi.ac.uk/pdbsum/6g6l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g6l ProSAT]</span></td></tr> |
| - | [[Category: Allen, M | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/MYC_HUMAN MYC_HUMAN]] Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:[http://omim.org/entry/113970 113970]]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MYC_HUMAN MYC_HUMAN]] Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. [[http://www.uniprot.org/uniprot/MAX_HUMAN MAX_HUMAN]] Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Allen, M D]] | ||
[[Category: Zinzalla, G]] | [[Category: Zinzalla, G]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Myc/max]] | ||
Revision as of 07:18, 10 April 2019
The crystal structures of Human MYC:MAX bHLHZip complex
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