6qt9
From Proteopedia
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- | '''Unreleased structure''' | ||
- | + | ==Cryo-EM structure of SH1 full particle.== | |
+ | <StructureSection load='6qt9' size='340' side='right'caption='[[6qt9]], [[Resolution|resolution]] 3.80Å' scene=''> | ||
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[6qt9]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Haloarcula_hispanica_virus_sh1 Haloarcula hispanica virus sh1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QT9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QT9 FirstGlance]. <br> | ||
+ | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qt9 OCA], [http://pdbe.org/6qt9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qt9 RCSB], [http://www.ebi.ac.uk/pdbsum/6qt9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qt9 ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | Many of the largest known viruses belong to the PRD1-adeno structural lineage characterised by conserved pseudo-hexameric capsomers composed of three copies of a single major capsid protein (MCP). Here, by high-resolution cryo-EM analysis, we show that a class of archaeal viruses possess hetero-hexameric MCPs which mimic the PRD1-adeno lineage trimer. These hetero-hexamers are built from heterodimers and utilise a jigsaw-puzzle system of pegs and holes, and underlying minor capsid proteins, to assemble the capsid laterally from the 5-fold vertices. At these vertices proteins engage inwards with the internal membrane vesicle whilst 2-fold symmetric horn-like structures protrude outwards. The horns are assembled from repeated globular domains attached to a central spine, presumably facilitating multimeric attachment to the cell receptor. Such viruses may represent precursors of the main PRD1-adeno lineage, similarly engaging cell-receptors via 5-fold spikes and using minor proteins to define particle size. | ||
- | + | Assembly of complex viruses exemplified by a halophilic euryarchaeal virus.,Colibus L, Roine E, Walter TS, Ilca SL, Wang X, Wang N, Roseman AM, Bamford D, Huiskonen JT, Stuart DI Nat Commun. 2019 Mar 29;10(1):1456. doi: 10.1038/s41467-019-09451-z. PMID:30926810<ref>PMID:30926810</ref> | |
- | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
- | + | </div> | |
- | + | <div class="pdbe-citations 6qt9" style="background-color:#fffaf0;"></div> | |
- | [[Category: | + | == References == |
- | [[Category: | + | <references/> |
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Haloarcula hispanica virus sh1]] | ||
+ | [[Category: Large Structures]] | ||
[[Category: Bamford, D]] | [[Category: Bamford, D]] | ||
- | [[Category: | + | [[Category: Colibus, L De]] |
- | [[Category: Huiskonen, J | + | [[Category: Huiskonen, J T]] |
+ | [[Category: Ilca, S L]] | ||
+ | [[Category: Roine, E]] | ||
+ | [[Category: Roseman, A M]] | ||
+ | [[Category: Stuart, D I]] | ||
+ | [[Category: Walter, T S]] | ||
[[Category: Wang, N]] | [[Category: Wang, N]] | ||
- | [[Category: De Colibus, L]] | ||
- | [[Category: Stuart, D.I]] | ||
[[Category: Wang, X]] | [[Category: Wang, X]] | ||
+ | [[Category: Euryarcheal virus]] | ||
+ | [[Category: Sh1]] | ||
+ | [[Category: Virus]] |
Revision as of 07:30, 10 April 2019
Cryo-EM structure of SH1 full particle.
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