6r2e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human thymidylate synthase (hTS) interface variant Q62R== | |
| - | + | <StructureSection load='6r2e' size='340' side='right'caption='[[6r2e]], [[Resolution|resolution]] 2.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6r2e]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R2E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R2E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FFO:N-[4-({[(6S)-2-AMINO-5-FORMYL-4-OXO-3,4,5,6,7,8-HEXAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC+ACID'>FFO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=SCH:S-METHYL-THIO-CYSTEINE'>SCH</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r2e OCA], [http://pdbe.org/6r2e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r2e RCSB], [http://www.ebi.ac.uk/pdbsum/6r2e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r2e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN]] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thymidylate synthase]] | ||
[[Category: Mangani, M]] | [[Category: Mangani, M]] | ||
[[Category: Pozzi, C]] | [[Category: Pozzi, C]] | ||
| + | [[Category: Folate pathway]] | ||
| + | [[Category: Human thymidylate synthase]] | ||
| + | [[Category: Interface variant]] | ||
| + | [[Category: Q62r]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:32, 10 April 2019
Crystal structure of the human thymidylate synthase (hTS) interface variant Q62R
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