5v7z
From Proteopedia
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==SSNMR Structure of the Human RIP1/RIP3 Necrosome== | ==SSNMR Structure of the Human RIP1/RIP3 Necrosome== | ||
| - | <StructureSection load='5v7z' size='340' side='right' caption='[[5v7z]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | + | <StructureSection load='5v7z' size='340' side='right'caption='[[5v7z]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5v7z]] is a 8 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V7Z FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5v7z]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V7Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V7Z FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7z OCA], [http://pdbe.org/5v7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v7z RCSB], [http://www.ebi.ac.uk/pdbsum/5v7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7z ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v7z OCA], [http://pdbe.org/5v7z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v7z RCSB], [http://www.ebi.ac.uk/pdbsum/5v7z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v7z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The RIPK1-RIPK3 necrosome is an amyloid signaling complex that initiates TNF-induced necroptosis, serving in human immune defense, cancer, and neurodegenerative diseases. RIPK1 and RIPK3 associate through their RIP homotypic interaction motifs with consensus sequences IQIG (RIPK1) and VQVG (RIPK3). Using solid-state nuclear magnetic resonance, we determined the high-resolution structure of the RIPK1-RIPK3 core. RIPK1 and RIPK3 alternately stack (RIPK1, RIPK3, RIPK1, RIPK3, etc.) to form heterotypic beta sheets. Two such beta sheets bind together along a compact hydrophobic interface featuring an unusual ladder of alternating Ser (from RIPK1) and Cys (from RIPK3). The crystal structure of a four-residue RIPK3 consensus sequence is consistent with the architecture determined by NMR. The RIPK1-RIPK3 core is the first detailed structure of a hetero-amyloid and provides a potential explanation for the specificity of hetero- over homo-amyloid formation and a structural basis for understanding the mechanisms of signal transduction. | ||
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| + | The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex.,Mompean M, Li W, Li J, Laage S, Siemer AB, Bozkurt G, Wu H, McDermott AE Cell. 2018 May 17;173(5):1244-1253.e10. doi: 10.1016/j.cell.2018.03.032. Epub, 2018 Apr 19. PMID:29681455<ref>PMID:29681455</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5v7z" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Laage, S]] | [[Category: Laage, S]] | ||
[[Category: Li, J]] | [[Category: Li, J]] | ||
Revision as of 07:41, 10 April 2019
SSNMR Structure of the Human RIP1/RIP3 Necrosome
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