4o9h
From Proteopedia
(Difference between revisions)
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==Structure of Interleukin-6 in complex with a Camelid Fab fragment== | ==Structure of Interleukin-6 in complex with a Camelid Fab fragment== | ||
| - | <StructureSection load='4o9h' size='340' side='right' caption='[[4o9h]], [[Resolution|resolution]] 2.42Å' scene=''> | + | <StructureSection load='4o9h' size='340' side='right'caption='[[4o9h]], [[Resolution|resolution]] 2.42Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4o9h]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O9H FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4o9h]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O9H FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9h OCA], [http://pdbe.org/4o9h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o9h RCSB], [http://www.ebi.ac.uk/pdbsum/4o9h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9h ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL6, IFNB2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9h OCA], [http://pdbe.org/4o9h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o9h RCSB], [http://www.ebi.ac.uk/pdbsum/4o9h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. | [[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. | ||
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| + | ==See Also== | ||
| + | *[[Interleukin|Interleukin]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Camelus glama]] | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Blanchetot, C]] | [[Category: Blanchetot, C]] | ||
[[Category: Cambillau, C]] | [[Category: Cambillau, C]] | ||
Revision as of 08:13, 10 April 2019
Structure of Interleukin-6 in complex with a Camelid Fab fragment
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Categories: Camelus glama | Human | Large Structures | Blanchetot, C | Cambillau, C | Desmyter, A | Dreier, T | Hemrika, W | Hultberg, A | Klarenbeek, A | Kretz-rommel, A | Ongenae, N | Roovers, R C | Sadi, A S | Schragel, G | Spinelli, S | Wijdenes, J | Haard, H J.W De | Fab: all beta protein | Il6: all alpha protein | Immune system
